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Drug Resistance in Cancer Mechanisms and Models 1st Edition by James H Goldie, Andrew J Coldman ISBN 0521482739 9780521482738

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Drug Resistance in Cancer Mechanisms and Models 1st Edition James H. Goldie Digital Instant Download

Author(s): James H. Goldie, Andrew J. Coldman
ISBN(s): 9780521482738
Edition: 1
File Details: PDF, 2.83 MB
Year: 2009
Language: english
SKU: EB-2221300 Category: Tags: ,

Drug Resistance in Cancer Mechanisms and Models 1st Edition by James H Goldie, Andrew J Coldman – Ebook PDF Instant Download/Delivery: 0521482739, 9780521482738
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Product details:

ISBN 10: 0521482739 
ISBN 13: 9780521482738
Author: James H Goldie, Andrew J Coldman

Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.

Drug Resistance in Cancer Mechanisms and Models 1st Table of contents:

The Biological Basis of Cancer and the Problem of Drug Resistance

Tumour Growth, Stem Cells, and Experimental Chemotherapy

Molecular Aspects of Drug Resistance

Quantitative Descriptions of the Origins of Drug Resistance

Development and Exploration of the Random Mutation Model for Drug Resistance

Extensions of the Random Mutation Model for Drug Resistance

Clinical Predictions of the Random Mutation Model

Directed Versus Random Mutation and the Problem of Intrinsic Resistance

Some Final Thoughts on the Problem of Drug Resistance

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Tags: James H Goldie, Andrew J Coldman, Drug Resistance, Cancer Mechanisms