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Cytokine Knockouts Contemporary Immunology 2nd Edition by Giamila Fantuzzi ISBN 9781592594054 1592594050

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Cytokine Knockouts 2nd ed Contemporary Immunology 2nd Edition Giamila Fantuzzi Digital Instant Download

Author(s): Giamila Fantuzzi
ISBN(s): 9781588291943, 1588291944
Edition: 2
File Details: PDF, 20.61 MB
Year: 2003
Language: english
SKU: EB-2205256 Category: Tag:

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Product details:
ISBN 10: 1592594050
ISBN 13: 9781592594054
Author: Giamila Fantuzzi

Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
 

Cytokine Knockouts Contemporary Immunology 2nd Edition Table of contents:

Part I: Introduction to Cytokines and Immunology

Chapter 1: The Role of Cytokines in Immunity

  • Overview of Cytokines and Their Functions
  • Cytokine Receptors and Signal Transduction Pathways
  • The Immune System and Cytokine Interaction
  • Overview of Cytokine Families: Interleukins, Interferons, TNF, and Chemokines

Chapter 2: Cytokine Knockout Models in Immunology

  • Introduction to Knockout Technology
  • Mechanisms for Creating Cytokine Knockout Mice
  • Impact of Cytokine Deficiencies on Immune Responses
  • Ethical Considerations in the Use of Knockout Models

Part II: Cytokine Knockouts and Immune Development

Chapter 3: Knockouts in Innate Immunity

  • Impact of Cytokine Deletion on Innate Immune Cells
  • The Role of Cytokines in Macrophage, Dendritic Cell, and Neutrophil Function
  • Deficiencies in TNF, IL-1, IL-6, and Their Effects on Innate Immunity
  • Knockout Models of Inflammatory Responses

Chapter 4: Cytokine Knockouts and Adaptive Immunity

  • T-Cell and B-Cell Development in Cytokine Knockout Models
  • The Role of IL-2, IL-4, and IL-10 in T-Cell Differentiation
  • IL-12, IFN-γ, and the Regulation of Th1/Th2 Responses
  • Knockout Mice for Studying Autoimmune Diseases

Chapter 5: Cytokine Regulation of Hematopoiesis

  • The Role of Cytokines in Hematopoietic Stem Cell Differentiation
  • Knockouts of IL-3, GM-CSF, and Erythropoietin
  • Cytokine Signaling in Hematopoietic Progenitor Cells
  • Impact of Cytokine Knockouts on Bone Marrow Development

Part III: Cytokine Knockouts and Disease Models

Chapter 6: Cytokines in Inflammatory Diseases

  • Role of Cytokines in Autoimmune Diseases: Rheumatoid Arthritis, Lupus, and MS
  • Knockout Models in Chronic Inflammation and Disease Pathogenesis
  • TNF, IL-1, and IL-6 in Inflammatory Disease Models
  • Interventions Targeting Cytokines in Therapy

Chapter 7: Cytokine Knockouts in Infectious Disease

  • The Role of Cytokines in Host Defense Against Pathogens
  • Knockouts in the Study of Bacterial, Viral, and Fungal Infections
  • Cytokine Responses to Vaccination and Immune Memory
  • Cytokine Manipulation in Infection Models

Chapter 8: Cytokines in Cancer Immunology

  • The Dual Role of Cytokines in Tumorigenesis
  • Effects of Cytokine Deletion on Tumor Immunity
  • IL-10, IL-12, and IFN-γ in Cancer Models
  • Cancer Immunotherapy and Cytokine Targeting

Part IV: Advanced Topics and Applications

Chapter 9: Cytokine Knockouts in Tissue Regeneration and Repair

  • Cytokines in Wound Healing and Tissue Repair
  • Knockout Models of Fibrosis and Tissue Regeneration
  • The Role of Cytokines in Stem Cell Therapy and Tissue Engineering

Chapter 10: Cytokine Knockouts in Aging and Immune Senescence

  • Cytokine Modulation in the Aging Immune System
  • Knockouts in Studying Age-Related Immune Dysfunction
  • Cytokine Pathways in Longevity and Age-Related Diseases

Chapter 11: Technological Advances in Cytokine Knockout Research

  • CRISPR/Cas9 and Other Gene Editing Tools for Cytokine Knockouts
  • High-Throughput Screening and Cytokine Profiling
  • Advancements in Knockout Models and Transgenic Animals

Part V: Clinical Implications and Future Directions

Chapter 12: Therapeutic Potential of Cytokine Modulation

  • Cytokine Therapy in Autoimmune and Inflammatory Diseases
  • Cytokine Antagonists and Agonists in Clinical Trials
  • Cytokine-Based Vaccines and Cancer Immunotherapies
  • Challenges in Translating Cytokine Knockout Research to the Clinic

Chapter 13: Future Directions in Cytokine Knockout Research

  • Emerging Cytokine Targets for Disease Treatment
  • The Future of Cytokine Knockouts in Understanding Immune Diseases
  • Next-Generation Models for Studying Cytokine Function

Conclusion: Integrating Cytokine Knockouts into Immunology

  • Summary of Key Insights from Cytokine Knockout Studies
  • The Evolving Role of Cytokines in Immunology
  • Bridging Basic Science and Clinical Applications

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Giamila Fantuzzi,Cytokine Knockouts,Contemporary Immunology