Colorectal Cancer Methods and Protocols 1st Edition by Steven M Powell ISBN 1592590845 9781592590841

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ISBN 10: 1592590845 
ISBN 13: 9781592590841
Author: Steven M Powell

The contents of Colorectal Cancer: Methods and Protocols aim to instruct investigators in all the key genetic, cellular, and molecular biological methods of analyzing colorectal tumors. The focused techniques and assays are described in sufficient detail to allow researchers to start an experiment on colon tumors and proceed from beginning to end as if the expert in the field who has performed these studies were guiding them at the bench. Of note, most of the chapters in this volume are written by those scientists who p- neered these methods and assays in their respective fields. The chapters in Colorectal Cancer: Methods and Protocols describe “state of the art” methods to analyze colorectal tumors, ranging from gross mic- dissection of specimens to specific molecular analyses. Included are coverages of mutational assays, instability testing, immunohistochemical assays, chro- somal studies, and gene expression analyses. The goal of our volume is to facilitate the performance of colorectal tumor biological experiments by investigators at various levels of training—from graduate students and postdoctoral fellows to principal investigators who desire to advance our understanding of colon cancer development.

Colorectal Cancer Methods and Protocols 1st Table of contents:

Part I: Overview and Background

1. Epidemiology and Risk Factors of Colorectal Cancer

   • Global Incidence and Mortality

   • Genetic and Environmental Risk Factors

   • Lifestyle Influences

2. Pathophysiology and Molecular Biology

   • Tumorigenesis in Colorectal Cancer

   • Molecular Pathways and Genetic Mutations

   • Biomarkers for Diagnosis and Prognosis

3. Classification and Staging

   • Histological Types

   • TNM Staging System

   • Molecular Subtypes

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Part II: Diagnostic Methods

4. Screening and Early Detection

   • Colonoscopy Techniques and Protocols

   • Non-invasive Screening: FOBT, FIT, and DNA Tests

   • Imaging Modalities for Screening

5. Imaging and Radiology

   • CT Colonography

   • MRI and PET-CT in Diagnosis and Staging

   • Endoscopic Ultrasound

6. Pathological Evaluation and Biopsy Techniques

   • Tissue Sampling Methods

   • Histopathological Examination Protocols

   • Immunohistochemistry and Molecular Testing

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Part III: Therapeutic Approaches and Protocols

7. Surgical Management

   • Principles of Colorectal Cancer Surgery

   • Minimally Invasive Techniques

   • Postoperative Care and Complications

8. Radiation Therapy

   • Indications and Planning

   • Techniques and Dosimetry

   • Side Effect Management

9. Chemotherapy Protocols

   • Standard Regimens (FOLFOX, FOLFIRI, etc.)

   • Targeted Therapies and Immunotherapy

   • Managing Toxicities

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Part IV: Emerging Techniques and Research Protocols

10. Molecular Targeted Therapy

    • EGFR and VEGF Inhibitors

    • Personalized Medicine Approaches

11. Immunotherapy in Colorectal Cancer

    • Checkpoint Inhibitors

    • Adoptive Cell Transfer

    • Current Clinical Trials

12. Experimental and Novel Diagnostic Methods

    • Liquid Biopsy and Circulating Tumor DNA

    • Advanced Imaging and AI Integration

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Part V: Supportive Care and Survivorship

13. Management of Side Effects and Complications

    • Nutritional Support

    • Pain and Symptom Management

    • Psychosocial Support

14. Rehabilitation and Quality of Life

    • Post-treatment Surveillance Protocols

    • Long-term Follow-up Strategies

    • Survivorship Care Planning

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Tags: Steven M Powell, Colorectal Cancer, Protocols