Clinical Epidemiology Practice and Methods 2nd Edition by Patrick S Parfrey, Brendan J Barrett ISBN 1493924273 9781493924271
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ISBN 10: 1493924273
ISBN 13: 9781493924271
Author: Patrick S Parfrey, Brendan J Barrett
Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.
Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.
Clinical Epidemiology Practice and Methods 2nd Table of contents:
On Framing the Research Question and Choosing the Appropriate Research Design
Patrick S. Parfrey, Pietro Ravani
Pages 3-18
Research Ethics for Clinical Researchers
John D. Harnett, Richard Neuman
Pages 19-30
Definitions of Bias in Clinical Research
Geoffrey Warden
Pages 31-48
Longitudinal Studies
Front Matter
Pages 49-49
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Longitudinal Studies 1: Determination of Risk
Sean W. Murphy
Pages 51-69
Longitudinal Studies 2: Modeling Data Using Multivariate Analysis
Pietro Ravani, Brendan J. Barrett, Patrick S. Parfrey
Pages 71-92
Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions
Pietro Ravani, Brendan J. Barrett, Patrick S. Parfrey
Pages 93-131
Longitudinal Studies 4: Matching Strategies to Evaluate Risk
Matthew T. James
Pages 133-143
Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease
Navdeep Tangri, Claudio Rigatto
Pages 145-156
Randomized Controlled Clinical Trials
Front Matter
Pages 157-157
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Randomized Controlled Trials 1: Design
Bryan M. Curtis, Brendan J. Barrett, Patrick S. Parfrey
Pages 159-175
Randomized Controlled Trials 2: Analysis
Robert N. Foley
Pages 177-190
Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes
Michelle M. Richardson, Megan E. Grobert, Klemens B. Meyer
Pages 191-206
Randomized Controlled Trials 4: Biomarkers and Surrogate Outcomes
Claudio Rigatto, Brendan J. Barrett
Pages 207-224
Randomized Controlled Trials 5: Determining the Sample Size and Power for Clinical Trials and Cohort Studies
Tom Greene
Pages 225-247
Randomized Controlled Trials 6: On Contamination and Estimating the Actual Treatment Effect
Patrick S. Parfrey
Pages 249-259
Randomized Controlled Trials 7: Analysis and Interpretation of Quality-of-Life Scores
Robert N. Foley, Patrick S. Parfrey
Pages 261-272
Randomized Controlled Trials: Planning, Monitoring, and Execution
Elizabeth Hatfield, Elizabeth Dicks, Patrick S. Parfrey
Pages 273-286