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Circular Dichroism Theory and Spectroscopy 1st Edition by David S Rodgers, Stephen C Wilhite, David S Rodgers ISBN 1612091997 9781612091990

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Circular Dichroism Theory and Spectroscopy Theory and Spectroscopy 1st Edition David S. Rodgers Digital Instant Download

Author(s): David S. Rodgers; Stephen C. Wilhite; David S. Rodgers
ISBN(s): 9781612091990, 1612091997
Edition: 1
File Details: PDF, 28.59 MB
Year: 2011
Language: english
SKU: EB-51795280 Category: Tags: ,

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ISBN 10: 1612091997 
ISBN 13: 9781612091990
Author: David S Rodgers, Stephen C Wilhite, David S Rodgers

Circular dichroism (CD) refers to the differential absorption of left and right circularly polarised light. This phenomenon is exhibited in the absorption bands of optically active chiral molecules. CD spectroscopy has a wide range of applications in many different fields. Most notably, UV CD is used to investigate the secondary structure of proteins. This book presents current research in the study of circular dichroism, including a study of the peculiarities of the circular dichroism spectra of double-stranded DNA cholesteric liquid-crystalline dispersions; magnetic circular dichroism in electron microscopy; and, the application of CD spectroscopy for short peptides such as the human immunodeficiency virus type 1 (HIV-1) inhibitor.

Circular Dichroism Theory and Spectroscopy 1st Table of contents:

  1. Chapter 1: Basic Principles of Circular Dichroism

    • Light and Electromagnetic Waves

    • Polarization of Light

    • The Concept of Circular Polarization

    • Circular Dichroism and Optical Activity

  2. Chapter 2: Theoretical Foundations of Circular Dichroism

    • Molecular Basis of CD

    • Absorption of Circularly Polarized Light by Chiral Molecules

    • The Link Between Molecular Structure and CD Spectra

    • Relationship Between Absorbance and CD Signal

  3. Chapter 3: Instrumentation and Measurement Techniques

    • CD Spectrometers: Components and Operation

    • Factors Affecting CD Measurements: Temperature, Concentration, Solvent

    • Calibration of CD Instruments

    • Practical Aspects of CD Spectra Acquisition

  4. Chapter 4: Applications of Circular Dichroism Spectroscopy

    • Conformational Analysis of Proteins and Nucleic Acids

    • Determining Secondary and Tertiary Structures of Biomolecules

    • Monitoring Protein Folding and Unfolding

    • Analyzing Protein-Ligand Interactions Using CD

  5. Chapter 5: CD in Structural Biology

    • Structural Determination of Proteins and Nucleic Acids

    • The Role of CD in Folding Pathways and Mechanisms

    • Using CD to Study Chiral Pharmaceuticals and Therapeutics

    • Applications in Characterizing Protein Aggregation and Misfolding

  6. Chapter 6: CD in the Study of Chiral Compounds

    • Understanding Chiral Centers and Optical Isomerism

    • CD Spectroscopy in the Study of Enantiomers

    • Applications of CD in Organic Chemistry and Drug Development

  7. Chapter 7: Advanced CD Techniques

    • Time-Resolved CD Spectroscopy

    • Circularly Polarized Luminescence (CPL) and Its Relation to CD

    • Fourier Transform CD Spectroscopy

    • Synchrotron Radiation CD (SRCD) and Its Applications

  8. Chapter 8: Data Analysis and Interpretation of CD Spectra

    • Analyzing CD Spectra: Methods and Approaches

    • Deconvolution of CD Spectra for Secondary Structure Estimation

    • Using CD for Structural Predictions

    • Common Pitfalls in CD Data Interpretation

  9. Chapter 9: CD and Its Integration with Other Spectroscopic Techniques

  • Combining CD with UV-Vis, Fluorescence, and NMR Spectroscopy

  • Using CD in Multidimensional Spectroscopic Studies

  • The Synergy Between CD and X-ray Crystallography or Cryo-EM

  • Advantages of Multi-technique Approaches

  1. Chapter 10: CD in Industrial and Pharmaceutical Applications

  • Applications in Biopharmaceutical Development and Quality Control

  • Use of CD for Monitoring Protein Purity and Stability

  • Applications in the Design and Production of Biologic Drugs

  • CD in the Evaluation of Drug Receptor Binding

  1. Chapter 11: Future Directions in Circular Dichroism Spectroscopy

  • Emerging Trends and Technologies in CD

  • Enhancements in CD Instrumentation and Sensitivity

  • The Role of CD in Systems Biology and Biotechnology

  • The Future of CD in Drug Discovery and Personalized Medicine

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Tags: David S Rodgers, Stephen C Wilhite, David S Rodgers, Circular Dichroism, Spectroscopy