Cancer Epigenetics Biomolecular Therapeutics for Human Cancer 1st Edition by Antonio Giordano, Marcella Macaluso ISBN B008BQ4NNA 9780471710967

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Cancer Epigenetics Biomolecular Therapeutics for Human Cancer 1st Edition Table of contents:

• Chapter 1: Introduction to Cancer Epigenetics

  • Overview of cancer and the genetic mutations driving cancer.
  • The concept of epigenetics: DNA methylation, histone modification, and non-coding RNAs.
  • The role of epigenetic modifications in tumorigenesis.

• Chapter 2: Mechanisms of Epigenetic Alterations in Cancer

  • DNA methylation and its impact on gene silencing.
  • Histone modifications and their role in chromatin remodeling.
  • MicroRNAs and long non-coding RNAs in the regulation of gene expression.
  • Genetic vs. epigenetic changes in cancer cells.

• Chapter 3: Epigenetic Biomarkers in Cancer Diagnosis and Prognosis

  • The identification of epigenetic biomarkers for early detection.
  • How epigenetic alterations can be used to predict cancer progression and patient outcomes.
  • Current advancements in epigenetic biomarkers for various cancers.

• Chapter 4: Epigenetic Therapy: Principles and Strategies

  • Overview of epigenetic therapies: small molecules, gene therapy, and CRISPR/Cas9 technology.
  • Inhibitors of DNA methylation and histone deacetylases.
  • The challenges of developing epigenetic drugs for clinical use.
  • Combining epigenetic therapy with traditional cancer treatments.

• Chapter 5: DNA Methylation and Histone Modifications in Human Cancers

  • Detailed exploration of DNA methylation and histone modification patterns in different cancers.
  • Case studies: lung, breast, prostate, and colorectal cancers.
  • The role of specific methylation and histone modifications in cancer metastasis.

• Chapter 6: Epigenetic Regulation of Tumor Suppressors and Oncogenes

  • The impact of epigenetic changes on tumor suppressor genes (e.g., p53, BRCA1) and oncogenes (e.g., MYC, KRAS).
  • Mechanisms by which epigenetic silencing and activation contribute to cancer.
  • Targeting epigenetic regulation for cancer therapy.

• Chapter 7: Epigenetic Reprogramming and Cancer Stem Cells

  • The concept of cancer stem cells and their role in tumor initiation and resistance to therapy.
  • How epigenetic changes contribute to the maintenance and differentiation of cancer stem cells.
  • Epigenetic strategies to target cancer stem cells.

• Chapter 8: Epigenetic Drugs and Clinical Trials

  • Overview of current epigenetic drugs in clinical development.
  • Clinical trial results and the challenges of epigenetic therapies.
  • The potential for combination therapies involving epigenetic drugs.

• Chapter 9: Cancer Immunotherapy and Epigenetics

  • The role of epigenetic modifications in immune evasion by cancer cells.
  • How epigenetic therapies can enhance the effectiveness of cancer immunotherapy.
  • Synergistic approaches involving immunotherapy and epigenetic modulation.

• Chapter 10: Future Directions in Cancer Epigenetics and Therapeutics

  • Emerging trends in cancer epigenetics research.
  • The future of epigenetic biomarkers in personalized cancer therapy.
  • Technological advances: Single-cell epigenomics, CRISPR/Cas9, and high-throughput screening for epigenetic drug discovery.

• Conclusion: The Promise and Challenges of Epigenetic Therapeutics

  • Recap of the key insights on the role of epigenetics in cancer.
  • The potential of epigenetic therapies to revolutionize cancer treatment.
  • Final thoughts on overcoming the challenges in epigenetic research and clinical application.

• Appendices

  • Glossary of key terms in cancer epigenetics.
  • Methodologies used in epigenetic research (e.g., ChIP-Seq, bisulfite sequencing).
  • References for further reading and research in cancer epigenetics.

• References

  • A comprehensive list of references cited throughout the book.

• Index

  • An alphabetical index of key terms, figures, and topics discussed in the book.

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