Bone Marrow Transplantation Across Major Genetic Barriers 1st Edition by Yair Reisner, Massimo F Martelli ISBN 9814271268 9789814271264

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Product details:

ISBN 10: 9814271268
ISBN 13: 9789814271264
Author: Yair Reisner, Massimo F Martelli

Bone Marrow Transplantation Across Major Genetic Barriers 1st Table of contents:

Introduction

• Crossing the HLA Barrier in SCID Patients

• The Experimental Basis for “Megadose” Transplants in Leukemia Patients

• How “Megadose” Transplants Overcome the Immune Barrier

• Initial Evidence for Tolerance Induction

• A Major Remaining Challenge: Enhancing Immune Reconstitution

• References

The Haploidentical Option for High-Risk Hematological Malignancies

Introduction

• Overcoming HLA-Histocompatibility Barriers

• Clinical Outcomes

  • Engraftment and GvHD

  • Leukemia Relapse

  • Non-Leukemic Mortality

  • Event-Free Survival

• Haploidentical SCT Based on Feto-Maternal Microchimaerism

• Conclusions

• References

Haploidentical Allogeneic Hematopoietic Cell Transplantation in Adults Using CD3/CD19 Depletion

Introduction

• Haplo RIC Using CD3/CD19-depleted Grafts

• Literature

Unmanipulated HLA-Mismatched/Haploidentical Blood and Marrow Hematopoietic Stem Cell Transplantation

Introduction

• Clinical Results of HLA-Mismatched/Haploidentical HSCT

• Establishment of the GIAC Protocol

• Clinical Results

• Engraftment

• Graft-versus-Host Disease

• Relapse and Management

• Transplant-related Mortality and Survival

• Posttransplant Immune Reconstitution

• Immune Tolerance Basis for Unmanipulated HLA-Mismatched Blood and Marrow HSCT

• Simultaneous Induction of T Cell Tolerance

• Maintaining T Cell Hyporesponsiveness

• Combination of Immunologic Suppressive Agents

• Conclusions

• References

Alloanergization in Haploidentical Hematopoietic Stem Cell Transplantation

Introduction

• Immunological Basis of Alloanergization

• Previous Clinical Studies

• Patients, Donors and Preparative Regimen

• Ex Vivo Alloanergization of Bone Marrow

• Pharmacological GvHD Prophylaxis and Supportive Care

• Engraftment and Transplant-Related Mortality

• GvHD

• Viral Reactivation and Infection

• Immune Reconstitution

• Outcome Summary

• In Vitro Studies of Alloanergization Efficacy and Specificity

• Clinical Trials and New Studies

• Stem Cell Source and Conditioning Regimen

• Donor T Cell and Allostimulator Sources

• Timing and Dose Escalation of Alloanergized Donor T Cells

• Measurement of Functional Antigen-specific Immune Reconstitution

• Final Summary

• References

Hematopoietic Stem Cell Transplantation Across Genetic Barriers Using Nonmyeloablative Conditioning

Introduction

• Strategies to Overcome HLA Barriers

• Effective T Cell Depletion

• Early and Recent Advances in T Cell Depletion

• Positive CD34 Selection and CD3+/CD19+ Depletion

• In Vivo T Cell Depletion Using Alemtuzumab or ATG

• Rationale for Nonmyeloablative Conditioning

• Results from Major Centers

• Strategies to Improve Outcomes

  • Natural Killer Cell / KIR Ligand Effects

  • Nonfetal Maternal Antigen Benefits

  • Selective T Cell Depletion

  • Cotransplantation of Mesenchymal Stem Cells

  • Donor Lymphocyte Infusion

  • Adoptive Immunotherapy and Vaccination

• Conclusions

• References

Deploying Natural Killer Cell Allotherapy in HLA-Haplotype-Mismatched Hematopoietic Stem Cell Transplantation

Introduction

• NK Cell Alloreactivity in Preclinical and Clinical Settings

• Guidelines for NK-Alloreactive Donor Selection

• References

Adoptive Immunotherapy for Infectious Complications After Allogeneic Hematopoietic Stem Cell Transplantation

Introduction

• Post-Transplant Infections (CMV, EBV, Adenovirus, Fungal)

• Adoptive T Cell Therapy

• Donor Lymphocyte Infusions

• Depletion of Alloreactive T Cells

• Enrichment of Antigen-specific T Cells

• Clinical Trials and Outcomes

• Conclusions

• References

The Challenge in Hematopoietic Stem Cell Transplantation: Shortening the Immunodeficiency Period

Introduction

• Depletion of Alloreactive T Cells

• Antiviral Immunotherapy

• Ex Vivo Expansion of Progenitor Cells

• References

Treatment of Adenovirus Infection After Haploidentical Stem Cell Transplantation in Children

Introduction

• Adenovirus Structure and Immunity

• Incidence, Risk Factors, and Diagnosis

• Clinical Symptoms and Pharmacologic Treatment

• Adoptive T Cell Transfer

• Conclusion and References

Regulatory T Cell Therapy for Immunomodulation After Allogeneic Hematopoietic Cell Transplantation

Introduction

• Role of Regulatory T Cells in GvHD and Immunity

• Impact of Immunosuppressive Agents

• Isolation and Expansion Techniques

• Clinical Trials

• Summary and References

Pathogen-Induced Immune Regulation in Transplantation

Introduction

• Fungi and Immunity

• Role of Dendritic Cells

• Induction of Protective Tolerance

• Immunotherapeutic Perspectives

• References

Immune Reconstitution After Haploidentical Hematopoietic Stem Cell Transplantation

Introduction

• Factors Affecting Immune Competence Development

• Conditioning, T Cell Depletion, Stem Cell Source, Age, GvHD

• Immunophenotypic and Functional Analysis

• Strategies to Improve Immune Reconstitution

• Cytokine Therapy, Growth Factors, Adoptive Cellular Therapy

• References

The Role of the Thymus in Hematopoietic Stem Cell Transplantation

Introduction

• Thymic Function in T Cell Maturation and Export

• Pathways of Posttransplant T Cell Regeneration

• Limitations and Dysfunction in Thymic Regeneration

• Clinical Implications and Interventions

• References

Human T Cell Differentiation: New Techniques, Old Challenges

Introduction

• Hematopoietic Stem Cells and T Cell Potency

• T Cell Development and Selection Models

• Notch Signaling and NK Cell Development

• Conclusions and Future Directions

• References

Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation

Introduction

• Target Antigen Identification

• TCR Gene Transfer and Therapy Limitations

• Strategies to Improve Adoptive Therapy

• Conclusions and Future Directions

• References

Alloreactive T Cells for the Treatment of Leukemia

Introduction

• Minor Histocompatibility Antigens and Tissue Distribution

• Clinical Relevance and Beneficial Responses

• Adoptive Transfer of Alloreactive T Cells

• Summary and References

Mobilization of Hematopoietic Stem and Progenitor Cells

Introduction

• Clinical and Preclinical Aspects

• Cytokine and Chemokine-Induced Mobilization

• Mechanistic Insights and Microenvironmental Factors

• Future Directions and References

A Revolutionary Bone Marrow Transplantation (BMT) Method

Introduction

• Discovery and Applications of IBM-BMT

• Use in Organ Transplantation, Regeneration Therapy, and Tumor Treatment

• Novel Methods Superior to Conventional BMT

• Conclusions and Future Directions

• References

Hematopoietic Cell Transplantation for Induction of Transplantation Tolerance: From Animal Models to Clinical Application

Introduction

• Tolerance Induction by Allogeneic Hematopoietic Cell Transplantation

• Mixed Chimerism Approaches

• Treatment of Hematologic Malignancies

• Future Directions

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Tags: Yair Reisner, Massimo F Martelli, Bone Marrow