Biotechnology Annual Review 13 1st Edition by M Raafat El Gewely ISBN 0444530320 9780444530325

Biotechnology Annual Review 13 1st Edition by M Raafat El Gewely – Ebook PDF Instant Download/Delivery: 0444530320, 9780444530325
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ISBN 10: 0444530320 
ISBN 13: 9780444530325
Author: M Raafat El Gewely

Biotechnology Annual Review 13 1st Table of contents:

Chapter 1. Toward a New Era in Sequencing

• Sequencing Technologies of the Next Generation

• Comparison: New Fast Sequencing Technique vs. Established Sanger Method

• Applications of the Genome Sequencer 20 System

• References

Chapter 2. Optimizing Scaleup Yield for Protein Production: Computationally Optimized DNA Assembly (CODA)

• Introduction

• Codon Pair Utilization Patterns Are Highly Biased

• Over-Represented Codon Pairs Are Translated Slowly

• Over-Represented Codon Pairs Occur at Protein Structural Boundaries

• Misplaced and Over-Represented Codon Pairs Can Inhibit Protein Expression

• ‘Hot Rod’ Genes Produce Proteins at High Levels

• Applications of CODA Technologies in Modern Biological Drug, Diagnostics, and Vaccine Development

• References

Chapter 3. Engineering, Expression, Purification, and Production of Recombinant Thermolysin

• Abbreviations

• Introduction

• Engineering and Expression of Recombinant Thermolysin

• Purification of Recombinant Thermolysin

• Future Perspectives

• Conclusion

• Acknowledgments

• References

Chapter 4. Preparation of Recombinant Vaccines

• Introduction

• The Different Systems to Produce Recombinant Vaccines

• Vaccine Adjuvants, Formulation, and Delivery

• The Use of Virus-Like Particles as Foreign Antigen Carrier Systems

• Conclusion

• References

Chapter 5. Advances in Antibody Manufacturing Using Mammalian Cells

• Introduction

• Upstream Considerations

• Downstream Considerations

• Conclusions

• References

Chapter 6. Pharming and Transgenic Plants

• Introduction

• Plants Have a High Potential for Pharmaceutical Protein Production

• Current Limitations of the Plant Expression System

• Optimization of Plant Production Platforms for Lower Proteolytic Activity and Humanized Glycosylation

• Emerging Plant Expression Systems for Molecular Farming

• Conclusion

• References

Chapter 7. Porous Silicon Protein Microarray Technology and Ultra-/Superhydrophobic States for Improved Applications

• Preface

• Introduction

• Porous Silicon – A Novel 3D Substrate for Protein Microarray Technology

• Effect of Porous Texture on Microarray Data Quality

• Superhydrophobic and Ultrahydrophobic States on Porous Silicon

• MS Compatible Protein Arrays/Dual-Readout Chips

• Accelerated Protein Digestion and Analyte Enrichment in Nanovials

• Superhydrophobic MALDI-TOF MS Target Anchor Chips

• Conclusions

• Acknowledgments

• References

Chapter 8. Production of Plasmid DNA for Pharmaceutical Use

• Introduction

• Plasmid Production

• Conclusions

• References

Chapter 9. Potentials of Phenolic Molecules of Natural Origin and Their Derivatives as Anti-HIV Agents

• Abbreviations Used

• Introduction

• AIDS and Its Therapy

• Plant Materials and Extracts Against HIV-1: Few Examples

• In Silico Approaches for Discovery of Anti-HIV Molecules from Natural Products

• Docking and Virtual Screening

• Caffeic Acid Derivatives from Food Supplements Against HIV

• The HIV-1 Life Cycle and Mechanism of Action of Anti-HIV Compounds from Medicinal Plants

• Phenolics – A Promising Class of Molecules Against HIV

• Some Biological Activities of Phenolics

• Phenolics Acting on Viral Targets

• Chemogenomics in Anti-HIV Drug Discovery

• Conclusions, Perspectives, and Recommendations

• Acknowledgments

• References

Chapter 10. Ganoderma Lucidum and Its Pharmaceutically Active Compounds

• Introduction

• G. Lucidum Cultivation Methods

• Cultivation of Fruit Bodies on Natural Wood Logs

• Cultivation of Fruit Bodies on Sawdust Substrates

• Cultivation of G. Lucidum Mycelia in a Bioreactor

• Main Pharmacologically Active Compounds in G. Lucidum

• Triterpenoids from Ganoderma Mushrooms

• Polysaccharides from Ganoderma Fruit Bodies and Mycelia

• Regulation and Protection of Cells

• Peptidoglycans and Proteins

• Other Compounds

• Formulations, Market Products, and Clinical Trials

• Conclusion

• References

Chapter 11. Citric Acid Production

• Introduction

• Uses and Occurrence

• Strains for Citric Acid Production

• Biochemistry

• Substrates

• Production Processes

• Product Recovery

• Economic Aspects

• Citric Acid World Production

• References

Chapter 12. Using Nanotechnology to Improve the Characteristics of Antineoplastic Drugs: Improved Characteristics of Paclitaxel and nab-Paclitaxel

• Introduction

• Paclitaxel

• nab-Paclitaxel

• Nonclinical Studies with nab-Paclitaxel

• Clinical Studies with nab-Paclitaxel

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