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Bioinformatics and Drug Discovery 2nd Edition by Kubilay Demir, Michael Boutros, Richard S Larson ISBN 1617799653 9781617799655

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Bioinformatics and Drug Discovery 2nd Edition Kubilay Demir Digital Instant Download

Author(s): Kubilay Demir, Michael Boutros (auth.), Richard S. Larson (eds.)
ISBN(s): 9781617799655, 1617799653
Edition: 2
File Details: PDF, 7.23 MB
Year: 2012
Language: english
SKU: EB-4289302 Category: Tags: , ,

Bioinformatics and Drug Discovery 2nd Edition by Kubilay Demir, Michael Boutros, Richard S Larson – Ebook PDF Instant Download/Delivery: 1617799653, 9781617799655
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Product details:

ISBN 10: 1617799653 
ISBN 13: 9781617799655
Author: Kubilay Demir, Michael Boutros, Richard S Larson

This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical informatics. The chapters discuss new methods to study target identification, genome analysis, cheminformatics, protein analysis, and text mining. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, software workflows, reagents and on-line resources, together with step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls.

Bioinformatics and Drug Discovery 2nd Table of contents:

  1. Cell Perturbation Screens for Target Identification by RNAi

  2. Using Functional Genomics to Identify Drug Targets: A Dupuytren’s Disease Example

  3. Functional Characterization of Human Genes from Exon Expression and RNA Interference Results

  4. Barcode Sequencing for Understanding Drug–Gene Interactions

  5. Basic Microarray Analysis

  6. From Microarray to Biological Networks

  7. Microarray Analysis in Drug Discovery and Clinical Applications

  8. Ontology‑Driven Approaches to Analyzing Data in Functional Genomics

  9. Gene Evolution and Drug Discovery

  10. Standardization of Microarray and Pharmacogenomics Data

  11. Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics

  12. Protein Interactions Probed with Mass Spectrometry

  13. Discovering New Drug‑Targeting Sites on Flexible Multidomain Protein Kinases

  14. Nuclear Magnetic Resonance‑Based Screening Methods for Drug Discovery

  15. Receptor‑Binding Sites

  16. In Silico Protein Design

  17. Chemical Database Preparation for Compound Acquisition or Virtual Screening

  18. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro‑Array and Gene Expression Data

  19. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance

  20. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection

  21. Linking Variants from Genome‑Wide Association Analysis to Function via Transcriptional Network Analysis

  22. Models of Excitation‑Contraction Coupling in Cardiac Ventricular Myocytes

  23. Integration of Multiple Ubiquitin Signals in Proteasome Regulation

  24. Bioinformatics Platform Development

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Tags: Kubilay Demir, Michael Boutros, Richard S Larson, Bioinformatics