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Battling Malaria Strengthening the U S Military Malaria Vaccine Program 1st Edition by Institute of Medicine, Medical Follow Up Agency, Committee on Military Malaria Vaccine Research A Program Review, Myron Levine, Patricia Graves ISBN 9780309659499 0309659493

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Battling Malaria Strengthening the U S Military Malaria Vaccine Program 1st Edition Committee On U.S. Military Malaria Vaccine Research – A Program Review Digital Instant Download

Author(s): Committee on U.S. Military Malaria Vaccine Research – A Program Review
ISBN(s): 9780309659499, 0309659493
Edition: 1
File Details: PDF, 1.01 MB
Year: 2006
Language: english
SKU: EB-1678518 Category: Tag:

Battling Malaria Strengthening the U S Military Malaria Vaccine Program 1st Edition by Institute of Medicine, Medical Follow-Up Agency, Committee on U.S. Military Malaria Vaccine Research: A Program Review, Myron M. Levine, Patricia M. Graves  – Ebook PDF Instant Download/Delivery: 9780309659499, 0309659493
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Product details: 

ISBN 10: 0309659493

ISBN 13: 9780309659499

Author: Institute of Medicine, Medical Follow-Up Agency, Committee on U.S. Military Malaria Vaccine Research: A Program Review, Myron M. Levine, Patricia M. Graves

Malaria is an infectious disease common to several parts of the world, including Africa, northern South America, and Asia. During their service in the military, U.S. active members may be sent to any part of the world, including parts of the world where Malaria is an issue. In Liberia in 2003, for example, there was a 28 percent attack rate in Marines who spent a short time ashore, and half of the 80 Marines affected needed to be evacuated to Germany. This was not only costly to the U.S. military but dangerous as well. To fight against this disease, there exists a Malaria Vaccine program in the U.S. military. However, there exists a variety of potential vaccine targets for the most severe and important form of malaria; malaria from the species Plasmodium falciparum. Issues also arise with the fact that there are three possible stages to create vaccines against—preerythrocytic, blood, or transmission. The Department of Defense (DoD), through the commanding general of the U.S. Army Medical Research and Materiel Command (USAMRMC), requested that the Institute of Medicine (IOM) conduct a programmatic review of the military Plasmodium falciparum malaria vaccine research and development program. There was to be a focus on vaccine against the preerythrocytic and blood stages. The IOM formed a committee of 11 experts with collective expertise in malaria vaccine research, parasite immunology, malarial biology, clinical trials and regulatory affairs, industrial and public-sector vaccine development, biologic products research and development (vaccinology), military research and development programs, tropical medicine, and public health. The committee focused different tasks including determining whether the DoD malaria vaccine research and development program is scientifically sound and able to achieve the vaccine program objectives within specified timelines, recommending how to overcome significant, identified barriers, and identifying major strategic goals and timelines based on the material received and presentations made by the DoD’s program representatives. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program presents the committee’s findings, current malaria vaccines, and recommendations for the development of the U.S. Military vaccine research.
 

Table of contents: 

  1. Introduction

  2. The Review Process and Inputs

  3. Scope and Organization of the Report

  4. The Malaria Threat and Need for a Vaccine

  5. Global Malaria Problem

  6. Military Malaria Problem

  7. Cost and Time Needed to Produce a Vaccine

  8. Malaria Vaccines

  9. Specific Military Needs with Respect to a Malaria Vaccine

  10. Malaria Vaccine Development

  11. Preerythrocytic Stages

  12. Erythrocytic Stages

  13. Multiantigen Multistage Approaches

  14. Scientific Barriers to Malaria Vaccine Development

  15. Insufficient Knowledge of Malaria Biology

  16. Lack of Understanding of Protective Immunity

  17. Inadequate Animal Models

  18. Poor Definition of Outcomes

  19. The Malaria Vaccine Technology Roadmap

  20. Department of Defense Scientific Contributions to the Global Malaria Vaccine Research Effort

  21. Status of Current Vaccine Candidates

  22. The U.S. Military Malaria Vaccine Research and Development Program – Scientific Aspects

  23. Malaria Threat

  24. Department of Defense Mandate for a Malaria Vaccine

  25. Malaria Vaccine Requirements

  26. Clinical Trials to Test Efficacy of a First-Generation Malaria Vaccine

  27. Current and Planned Scientific Program

  28. RTS,S

  29. Recombinant Proteins

  30. Gene-Based Vaccines and Prime-Boost Approaches

  31. Antigen Discovery Using Genomics and Proteomics

  32. Attenuated Sporozoites

  33. Planned Clinical Trials

  34. Overall Assessment of Scientific Program

  35. Organization and Management of the Program

  36. Program Management

  37. Project Management Structure

  38. IRB Approval Process for Clinical Trials

  39. Business and Intellectual Property Issues

  40. Communication and Resource Sharing

  41. Program Reorganization

  42. Previous Reports Addressing DoD Vaccine Development and Acquisition

  43. Human Resource Commitments

  44. Financial Commitment

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Tags: Institute of Medicine, Medical Follow Up Agency, Committee on Military Malaria Vaccine ResearchA Program ReviewMyron Levine, Patricia Graves