Base Excision Repair 1st Edition by Kivie Moldave, Amanda McCullough, Steven Lloyd, Guest Editors, Sankar Mitra, Samuel Wilson ISBN 0125400683 9780125400688
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ISBN 10: 0125400683
ISBN 13: 9780125400688
Author: Kivie Moldave, Amanda McCullough, Steven Lloyd, Guest Editors, Sankar Mitra, Samuel Wilson
This volume of Progress in Nucleic Acid Research and Molecular Biology represents research discussed during the DNA Base Excision Repair Workshop. This compilation of articles focuses on several recent observations highlighting the complexity of the base excision repair (BER) process in DNA repair. Focusing on the various facets of BER research, this book is a timely and highly beneficial reference for investigators in the DNA repair field. It will also aid scientists not directly involved in repair studies to obtain a comprehensive understanding of the current state of knowledge in the field.Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.
Key Features*Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology.* Presents contributions from top researchers* Includes abundant references
Base Excision Repair 1st Edition Table of contents:
Chapter 1: Introduction to Base Excision Repair
- 1.1 Overview of DNA Repair Mechanisms
- 1.2 The Discovery of Base Excision Repair
- 1.3 Key Players in BER: Enzymes and Proteins Involved
- 1.4 The Role of BER in Maintaining Genomic Stability
- 1.5 BER and Human Health: Implications in Cancer and Aging
Chapter 2: The Biochemical Mechanisms of Base Excision Repair
- 2.1 Overview of the BER Pathway
- 2.2 Recognition and Removal of Damaged Bases
- 2.3 Role of DNA Glycosylases in Base Excision
- 2.4 AP Endonucleases: The Next Step in BER
- 2.5 DNA Polymerases and Ligation in BER
- 2.6 Regulation of the BER Pathway
Chapter 3: The Role of DNA Glycosylases in Base Excision Repair
- 3.1 General Mechanisms of DNA Glycosylase Activity
- 3.2 Specific DNA Glycosylases Involved in BER: A Detailed Review
- 3.3 Substrate Specificity and the Repair of Oxidized Bases
- 3.4 DNA Glycosylases and Their Role in Mutagenesis and Cancer
- 3.5 Clinical Implications of Dysregulated DNA Glycosylases
Chapter 4: Single-Strand Break Repair and BER Cross-Talk
- 4.1 Overview of Single-Strand Breaks in DNA
- 4.2 Interaction Between BER and Other DNA Repair Pathways
- 4.3 Coordination of BER with Other Repair Mechanisms
- 4.4 The Role of BER in DNA Damage Signaling
- 4.5 Clinical Insights into Single-Strand Break Repair and BER
Chapter 5: The Regulation of Base Excision Repair
- 5.1 Cellular Regulation of BER Pathway Enzymes
- 5.2 Post-Translational Modifications of BER Proteins
- 5.3 BER and DNA Damage Response Networks
- 5.4 The Role of BER in Cell Cycle Checkpoints and Apoptosis
- 5.5 The Impact of BER Dysfunction on Disease Development
Chapter 6: BER in Eukaryotic Cells
- 6.1 The BER Pathway in Mammalian Cells
- 6.2 Localization of BER Components in the Nucleus
- 6.3 BER and Mitochondrial DNA Repair
- 6.4 BER in Stem Cells and Differentiating Cells
- 6.5 BER and Cancer Therapy: Targeting DNA Repair Mechanisms
Chapter 7: The Role of Base Excision Repair in Aging and Neurodegeneration
- 7.1 DNA Damage and the Aging Process
- 7.2 BER’s Role in Aging and Cellular Senescence
- 7.3 The Contribution of BER to Neurodegenerative Diseases
- 7.4 Therapeutic Strategies Targeting BER in Aging and Disease
- 7.5 Clinical Insights into BER Dysfunction in Alzheimer’s and Parkinson’s Disease
Chapter 8: BER in Prokaryotes and Organisms with Unconventional DNA Repair Systems
- 8.1 The Role of BER in Bacteria
- 8.2 Unique Features of Prokaryotic BER Pathways
- 8.3 BER in Other Organisms: Yeast, Plants, and Viruses
- 8.4 Comparative Analysis of BER Systems Across Species
- 8.5 Implications for Drug Development and Environmental Response
Chapter 9: Emerging Topics in Base Excision Repair Research
- 9.1 New Insights into the BER Enzyme Landscape
- 9.2 BER and Cancer: Opportunities for Targeted Therapies
- 9.3 The Potential for Gene Editing and BER Manipulation
- 9.4 Advances in BER Detection and Biomarker Development
- 9.5 Future Directions in BER Research and Clinical Applications
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Kivie Moldave,Amanda McCullough,Steven Lloyd,Guest Editors,Sankar Mitra,Samuel Wilson,Base Excision Repair