Sale!

Barile s Clinical Toxicology Principles and Mechanisms 3rd Edition by Frank A Barile ISBN 1498765300 9781498765305

Original price was: $50.00.Current price is: $35.00.

Barile s clinical toxicology principles and mechanisms Third Edition Barile Digital Instant Download

Author(s): Barile, Frank A
ISBN(s): 9781498765305, 1498765300
Edition: Third edition
File Details: PDF, 14.87 MB
Year: 2019
Language: english
SKU: EB-10502028 Category: Tags: ,

Barile s Clinical Toxicology Principles and Mechanisms 3rd Edition by Frank A Barile – Ebook PDF Instant Download/Delivery: 1498765300, 9781498765305
Full download Barile s Clinical Toxicology Principles and Mechanisms 3rd Edition after payment

Product details:

ISBN 10: 1498765300 
ISBN 13: 9781498765305
Author: Frank A Barile

As with the two previous editions, Barile’s Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. With special emphasis placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs, the new edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. The new edition presents the latest, up-to-date protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology. In addition, the effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered. KEY FEATURES • Discusses source of the drug or chemical, pharmacological and toxicological mechanisms of action, detection, identification, and treatment • Examines the complex interactions associated with clinical toxicological events • Emphasizes the signs and symptoms of diseases and pathology caused by toxins and clinical drugs • Covers effect of toxins on body systems and drug-induced adverse reactions • Offers a unique perspective for toxicology, pharmacology, pharmacy and health professions students The target audience for this book is undergraduate and graduate toxicology students, clinical pharmacy (Pharm.D.) students, emergency medical personnel, regulatory agencies, and other related health science professionals. It satisfies an essential need for a concise yet detailed authoritative, fundamental text addressing the current principles of clinical toxicology.

Barile s Clinical Toxicology Principles and Mechanisms 3rd Table of contents:

PART I: FUNDAMENTAL PRINCIPLES OF TOXICOLOGY

Chapter 1: Introduction

  • 1.1 Overview

  • 1.2 Basic Definitions

  • 1.3 Types of Toxicology

  • 1.4 Types of Toxicologists

  • References, Further Reading, Review Articles

Chapter 2: Risk Assessment and Regulatory Toxicology

  • 2.1 Risk Assessment (HIRA, Exposure, Hazard Characterization, etc.)

  • 2.2 Regulatory Toxicology (NRC, EPA, FDA, DEA, OSHA, etc.)

  • References, Further Reading, Review Articles

Chapter 3: Adverse Drug Reactions (ADRs)

  • 3.1 Clinical Adverse Effects

  • 3.2 Risk Factors for ADRs

  • 3.3 Treatment of ADRs and Poisoning

  • 3.4 Drug Detection and Identification

  • References

Chapter 4: Classification of Toxic Agents in Humans

  • By target organ, origin, application, physical state, biochemical properties

  • References

Chapter 5: Exposure

  • Routes: oral, inhalation, injection, etc.

  • Duration and Frequency

  • Toxicant Accumulation

  • References

Chapter 6: Toxicological Effects

  • Types of Responses

  • Chemical Interactions (Additive, Antagonistic, Synergistic…)

  • References

Chapter 7: Dose – Response

  • LD50, ED50, TD50, IC50

  • Therapeutic Index (TI)

  • References

Chapter 8: Animal Toxicity Testing

  • Human vs. Animal Comparison

  • Species Selection

  • IACUC and Ethical Considerations

  • Types of Toxicity Tests

Chapter 9: In Vitro Alternative Methods

  • Cell and Tissue Culture

  • Predictive Toxicology and Clinical Application

  • References

Chapter 10: Toxicokinetics

  • Absorption, Distribution, Metabolism, Excretion (ADME)

  • One- and Two-Compartment Models

  • Blood–Brain Barrier, Placenta…

Chapter 11: Drug–Receptor Interactions

  • Types of Receptors: Ion channels, GPCRs, Enzymes, Nuclear Receptors

  • Signal Transduction Mechanisms

Chapter 12: Toxicogenomics

  • Genetic Variability, DNA Damage, Epigenetic Toxicology

  • Methylation, Non-coding RNA Mechanisms

 PART II: TOXICITY OF THERAPEUTIC AGENTS

Chapters 13–23: Therapeutic Drug Classes

  • Sedatives/Hypnotics: Barbiturates, Benzodiazepines, Zolpidem…

  • Opioids and Derivatives

  • Sympathomimetics: Amphetamines, Cocaine, Nicotine…

  • Hallucinogens: LSD, PCP, MDMA, Marijuana…

  • Anticholinergics and Antipsychotics

  • Analgesics and Anti-inflammatories: Paracetamol, Aspirin, NSAIDs

  • Anabolic Steroids and Hormones

  • Cardiovascular Drugs: Digoxin, Beta Blockers, Calcium Channel Blockers

  • Antineoplastics (Chemotherapy Drugs)

  • Vitamins (Hypervitaminosis)

  • Herbal and Traditional Medicines

 PART III: TOXICITY OF NON-THERAPEUTIC AGENTS

Chapters 24–26: Environmental and Industrial Agents

  • Alcohols and Aldehydes: Ethanol, Methanol, Isopropanol, Formaldehyde

  • Toxic Gases: Carbon Monoxide, Cyanide, Respiratory Irritants, Asphyxiants

  • Heavy Metals: Arsenic, Lead, Mercury, Cadmium, Iron, etc.

  • Chelation Therapy for Heavy Metal Poisoning

People also search for Barile s Clinical Toxicology Principles and Mechanisms 3rd:

barile s clinical toxicology principles and mechanisms
    
barile’s clinical toxicology principles and mechanisms
    
barile’s clinical toxicology
    
barile’s clinical toxicology
    
clinical toxicology principles and mechanisms

Tags: Frank A Barile, Barile s Clinical, Toxicology