Bacteriophage Genetics and Molecular Biology 1st Edition by Stephen Mcgrath,Douwe Van Sinderen 9781904455141 190445514X

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ISBN 10:190445514X 
ISBN 13:9781904455141
Author:Stephen Mcgrath,Douwe Van Sinderen
Bacteriophages (viruses that infect bacteria) are fascinating organisms that have played and continue to play a key role in bacterial genetics and molecular biology. Phage can confer key phenotypes on their host – for example, converting a non-pathogenic strain into a pathogen – and they play a key role in regulating bacterial populations in all sorts of environments. The phage-bacterium relationship varies enormously, from the simple predator-prey model to a complex, almost symbiotic relationship that promotes the survival and evolutionary success of both. While infection of bacteria used in the fermentation industry can be very problematic and result in financial losses, in other scenarios, phage infection of bacteria can be exploited for industrial and/or medical applications. Interest in phage and phage gene products as potential therapeutic agents is increasing rapidly and is likely to have a profound impact on the pharmaceutical industry and biotechnology in general over the coming years. One potential application is the use of phage to combat the growing menace of antibiotic-resistant infections. Written by eminent international researchers actively involved in the disparate areas of bacteriophage research, this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current, most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype, and much more. The book will be essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology, and pharmaceutical companies, as well as in the food industry.

Bacteriophage Genetics and Molecular Biology 1st Table of contents:

1 The New Phage Biology: from Genomics to Applications • Olivia McAuliffe, R. Paul Ross, and Gerald F. Fitzgerald
2 Bacteriophage Bioinformatics and Genomics • Carlos A. Canchaya, Marco Ventura, and Douwe van Sinderen
3 Bacteriophage in the Environment • Markus G. Weinbauer, Martin Agis, Osana Bonilla-Findji, Andrea Malits, and Christian Winter
4 Bacteriophages and Food Fermentations • Eric Emond and Sylvain Moineau
5 Bacteriophages in Medicine • Andrzej Górski, Jan Borysowski, Ryszard Międzybrodzki, and Beata-Weber-Dąbrowska
6 Phage Therapy: the Western Perspective • Harald Brüssow
7 Bacteriophage–Host Interaction in Lactic Acid Bacteria • Christina Skovgaard Vegge, John Gerard Kenny, Lone Brøndsted, Stephen Mc Grath, and Douwe van Sinderen
8 Transfer of DNA from Phage to Host • Lucienne Letellier, Laure Plançon, and Pascale Boulanger
9 Prophages and their Contribution to Host Cell Phenotype • W. Michael McShan and Joseph J. Ferretti
10 Prophage Induction of Phage λ • John W. Little
11 Phage φ29: Membrane-associated DNA Replication and Mechanism of Alternative Infection Strategy • Wilfried J.J. Meijer, Daniel Muñoz-Espín, Virginia Castilla-Llorente, and Margarita Salas
12 Release of Progeny Phages from Infected Cells • Carlos São-José, João G. Nascimento, Ricardo Parreira, and Mário A. Santos

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Stephen Mcgrath,Douwe Van Sinderen,Molecular,Bacteriophage,Genetics