Applications of Toxicogenomics in Safety Evaluation and Risk Assessment 1st Edition by Darrell R Boverhof, B Bhaskar Gollapudi ISBN 0470449829 9780470449820
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Product details:
ISBN 10: 0470449829
ISBN 13: 9780470449820
Author: Darrell R. Boverhof, B. Bhaskar Gollapudi
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Table of contents:
Chapter 1. Toxicology, “Omics” Technologies, and Toxicogenomics: A Primer
Chapter 2. Introduction to Human Health Risk Assessment
Chapter 3. Practical Considerations for the Application of Toxicogenomics to Risk Assessment
Chapter 4. Approaches and Practical Considerations for the Analysis of Toxicogenomics Data
Chapter 5. Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis
Chapter 6. Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens
Chapter 7. Genomics in Characterizing Endocrine Toxicity
Chapter 8. Studying Organ-Specific Toxicity Using Gene-Expression Profiling
Chapter 9. Toxicogenomic Studies in Human Populations
Chapter 10. Toxicogenomics Applied to Ecological Risk Assessment
Chapter 11. Analysis of Transcriptomic Dose–Response Data for Toxicology and Risk Assessment
Chapter 12. Toxicogenomics as a Tool for Validating Animal-to-Human Extrapolations in Chemical Risk Assessment
Chapter 13. Toxicogenomics and Animal Alternatives
Chapter 14. Toxicogenomics and the Regulatory Framework
Chapter 15. Standardization of Gene-Expression Information for Safety Evaluation
Chapter 16. Applying Transcriptional Profiling in Drug Safety Evaluation
Chapter 17. Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach
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Tags: Darrell R Boverhof, B Bhaskar Gollapudi, Applications, Toxicogenomics, Safety, Evaluation, Risk, Assessment