Apoptosis and development 1st Edition by Hermann Steller ISBN 0124104258 9780124104259

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ISBN 10: 0124104258 
ISBN 13: 9780124104259
Author: Hermann Steller

Apoptosis and development 1st Table of contents:

Chapter One: Cell Death in C. elegans Development

• Abstract

1. Introduction

2. Core Apoptosis Regulators in C. elegans

3. The Core Apoptotic Pathway of C. elegans

4. Regulating Apoptosis

5. The Engulfment Genes and Their Roles in Cell Death

6. Linker Cell Death

7. Looking Ahead
   Acknowledgments

Chapter Two: Mitochondrial Cell Death Pathways in Caenorhabditis elegans

• Abstract

1. Introduction

2. Mitochondria: A Central Player in Mammalian Apoptosis

3. Programmed Cell Death in C. elegans

4. Mitochondrion Is an Important Component in C. elegans Programmed Cell Death

5. Concluding Remarks
   Acknowledgments

Chapter Three: Autophagy in Cell Life and Cell Death

• Abstract

1. Introduction

2. Autophagy Genes

3. Autophagy and Cell Survival

4. Autophagy and Cell Death

5. Conclusions
   Acknowledgments

Chapter Four: The End of the Beginning: Cell Death in the Germline

• Abstract

1. Overview of Cell Death Pathways

2. Death of Primordial Germ Cells

3. Germline Cell Death in the Adult Ovary

4. Cell Death in the Testis

5. Comparison of PCD in the Drosophila and Mammalian Ovary

6. Conclusion
   Acknowledgments

Chapter Five: The HOX–Apoptosis Regulatory Interplay in Development and Disease

• Abstract

1. Introduction

2. Hox Genes: Homeotic Genes with Master Regulatory Functions

3. Apoptosis: The Controlled Killing of Cells

4. Hox–Apoptosis Regulatory Interactions During Development

5. Interplay of Hox Genes and Apoptosis in the Disease Context

6. Concluding Remarks
   Acknowledgments

Chapter Six: Programmed Cell Death and Caspase Functions During Neural Development

• Abstract

1. Introduction

2. Neurotrophic Support for Neuronal or Glial Survival

3. Involvement in Morphogenesis

4. Elimination of Morphogen-Producing Cells

5. Intrinsic Regulation of the Number of Progeny from a Specific Cell Lineage

6. Canceling Developmental Errors

7. Neural Cell Death in Sensory System Development: The Visual System as a Model

8. The Role of Neural Cell Death in Tissue Remodeling

9. Glial Function in Controlling Neural Architecture by Elimination of Dead Cells

10. The Nonapoptotic Functions of Caspases in Neural Development

11. Neurite Pruning

12. Mechanisms that Control Nonapoptotic Caspase Activation

13. Transient or Weak Caspase Activation

14. Local Caspase Activation

15. Conclusion
    Acknowledgments

Chapter Seven: Regulation of Cell Death by IAPs and Their Antagonists

• Abstract

1. Introduction

2. IAP/Antagonist Interaction

3. Mitochondrial Association of IAP-Antagonists

4. The Role of Mammalian IAP-Antagonists

5. Transcriptional Regulation of Drosophila IAP-Antagonists

6. Posttranscriptional Regulation of IAP-Antagonists

7. The Role of IAP-Antagonists in Nervous System Development

8. IAPs and Their Antagonists in Sculpting Morphogenesis

9. Nonapoptotic Roles of IAPs in Morphogenesis, Cell Migration, and Proliferation

10. The Roles of IAPs in the Innate Immune Response

11. Concluding Remarks
    Acknowledgments

Chapter Eight: Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis

• Abstract

1. Introduction

2. Ubiquitin as Mediator of Signaling Events

3. Ub as Arbiter of Life and Death—TNF Signaling as Paradigm

4. Ub-Dependent Regulation of RIPK1 and the Ripoptosome

5. IAP-Mediated Regulation of Caspases

6. Concluding Remarks
   Acknowledgments

Chapter Nine: The Sound of Silence: Signaling by Apoptotic Cells

• Abstract

1. Apoptosis: A Silent Death?

2. Apoptotic Signals Dictate Immunological Responses to Cell Death

3. Apoptotic Cells Directly Influence Tissue Homeostasis and Growth Control

4. Apoptosis: A Loud Death
   Acknowledgments

Chapter Ten: Clearance of Apoptotic Cells and Pyrenocytes

• Abstract

1. Introduction

2. Apoptosis and Signal Transduction

3. The Engulfment of Apoptotic Cells

4. The Engulfment of Pyrenocytes

5. DNA Degradation in Macrophages

6. Perspectives

Chapter Eleven: Apoptotic Cell Clearance in Development

• Abstract

1. Introduction

2. Professional and Nonprofessional Phagocytes During Development

3. How Do Phagocytes “Sense” Apoptotic Cells?

4. How Do Phagocytes Recognize Apoptotic Cells?

5. Intracellular Phagocytic Machinery

6. How Do Phagocytes Become Phagocytic?

7. Why Are Living Cells Not Removed by Phagocytes?

8. Glial Phagocytosis of Apoptotic Neurons in the Developing CNS

9. Additional Examples of Apoptotic Cell Clearance During Development

10. Stress-Induced Upregulation of Phagocytosis During Development

11. Anti-Inflammatory Response Following Apoptotic Cell Clearance

12. Phagocytosis-Promoted PCD

13. Concluding Remarks
    Acknowledgments

Chapter Twelve: The Morphogenetic Role of Apoptosis

• Abstract

1. Introduction

2. Part I: Cytoskeletal Control of Apoptotic Cell Dynamics

3. Part II: Influence of Apoptotic Cells on Their Surroundings

4. Conclusion

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Tags: Hermann Steller, Apoptosis