Animal Models of Brain Tumors 1st Edition Lois A Lampson Ricardo Martínez Murillo Alfredo Martínez ISBN 1627032096 9781627032094

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ISBN 10: 1627032096  
ISBN 13: 9781627032094
Author: Lois A Lampson Ricardo Martínez Murillo Alfredo Martínez

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in “in vivo” experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results.

Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

Animal Models of Brain Tumors 1st Table of contents:

Part I: Introduction

1. Brain Tumor Models to Predict Clinical Outcome: Like the Phoenix?
   Lois A. Lampson

2. Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints
   Jose M. Orellana-Muriana

Part II: Animal Models Offer Insights into Human Brain Neoplasms

3. The VM Mouse Model of Glioblastoma Multiforme
   Thomas N. Seyfried, Laura M. Shelton, Leanne C. Huysentruyt

4. Oligodendroglioma Models
   Nanna Lindberg, Lene Uhrbom

5. Medulloblastoma Model
   Jasmine Lau, William A. Weiss

6. Learning about Retinoblastoma from Mouse Models that Missed
   David Cobrinik

7. Ependymoma Models
   Jesus Vaquero, Mercedes Zurita

8. Meningioma Models
   Jessica Rainey, Randy L. Jensen

9. Pituitary Models
   Walavan Sivakumar, William T. Couldwell

10. Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors
    Kelly Burrell, Elena Bogdanovic, Shahrzad Jalali, Gelareh Zadeh, Abhijit Guha

Part III: Cellular, Molecular, and Genetic Basis of Brain Tumors: Data from Animal Models

11. Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children
    Aparna Kaul, Ibrahim Hussain, David H. Gutmann

12. EGFR and Tumor-Suppressor Function in Brain Cancer Development
    Julie Lessard, Al Charest

Part IV: Therapies in the Treatment of Malignant Glioma: Data from Animal Models

13. Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts
    Hikmat Assi, Marianela Candolfi, Pedro R. Lowenstein, Maria G. Castro

14. Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models
    Kristen A. Batich, Bryan D. Choi, Duane A. Mitchell

15. Assessing Mechanisms of Glioblastoma Invasion
    Stephen M. Robbins, Donna L. Senger

Part V: Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism

16. Positron Emission Tomography (PET)-Based Molecular Imaging
    Yannic Waerzeggers, Thomas Viel, Sonja Schafers, Stefan Wagner, Andreas Faust, Burkhard Riemann, Klaus Kopka, Otmar Schober, Klaus Schafers, Andreas H. Jacobs

17. In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)
    Rui V. Simoes, Ana Paula Candiota, Margarida Julia-Sape, Carles Arus

18. Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research
    Andre Constantinesco, Christian Goetz, Philippe Choquet

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