Written by a leading expert on Aspirin-related research, this is the first comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever.
The text is written with a wide audience in mind and to be readily understandable for clinicians as well as biomedical researchers and pharmacologists alike. The content is up to date and includes the latest results of clinical and academic research, with a balanced view on the disputed properties of this famous drug.
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Acetylsalicylic Acid 1st Edition by Karsten Schror ISBN 3527321098 9783527321094
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Acetylsalicylic Acid 1st Edition Karsten Schrör Digital Instant Download
ISBN(s): 9783527321094, 3527321098
Edition: 1
File Details: PDF, 5.99 MB
Year: 2009
Language: english
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Product details:
ISBN 10: 3527321098
ISBN 13: 9783527321094
Author: Karsten Schror
Acetylsalicylic Acid 1st Table of contents:
1 General Aspects
1.1 History
1.1.1 Willow Bark and Leaves as Antipyretic, Anti-Inflammatory Analgesics
1.1.2 Salicylates as the Active Ingredient of Willow Bark and Other Natural Sources
1.1.3 Synthesis of Acetylsalicylic Acid and First Clinical Studies
1.1.4 Mode of Aspirin Action
1.1.5 Anti-Inflammatory/Analgesic Actions of Aspirin
1.1.6 Aspirin in the Cardiovascular System
1.1.7 Current Research Topics
1.2 Chemistry
1.2.1 Structures and Chemical Properties of Salicylates
1.2.2 Determination of Salicylates
2 Pharmacology
2.1 Pharmacokinetics
2.1.1 Absorption and Distribution
2.1.2 Biotransformation and Excretion
2.2 Cellular Modes of Action
2.2.1 Inhibition of Cyclooxygenases
2.2.2 COX-Independent Actions on Cell Function
2.2.3 Energy Metabolism
2.3 Actions on Organs and Tissues
2.3.1 Hemostasis and Thrombosis
2.3.2 Inflammation, Pain, and Fever
2.3.3 Aspirin and Malignancies
3 Toxicity and Drug Safety
3.1 Systemic Side Effects
3.1.1 Acute and Chronic Toxicity
3.1.2 Bleeding Disorders
3.1.3 Safety Pharmacology in Particular Life Situations
3.2 Organ Toxicity
3.2.1 Gastrointestinal Tract
3.2.2 Kidney
3.2.3 Liver
3.2.4 Audiovestibular System
3.3 Non-Dose-Related (Pseudo)allergic Actions of Aspirin
3.3.1 Aspirin Hypersensitivity (Widal’s Syndrome)
3.3.2 Urticaria/Angioedema, Stevens–Johnson and Lyell Syndromes
3.3.3 Reye’s Syndrome
4 Clinical Applications of Aspirin
4.1 Thromboembolic Diseases
4.1.1 Coronary Vascular Disease
4.1.2 Cerebrovascular Diseases
4.1.3 Peripheral Arterial Disease
4.1.4 Venous Thrombosis
4.1.5 Preeclampsia
4.1.6 Aspirin “Resistance”
4.2 Pain, Fever, and Inflammatory Diseases
4.2.1 Aspirin as an Antipyretic Analgesic
4.2.2 Arthritis and Rheumatism
4.2.3 Kawasaki Disease
4.3 Further Clinical Indications
4.3.1 Colorectal Cancer
4.3.2 Alzheimer’s Disease
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