Malaria Parasites Comparative Genomics Evolution and Molecular Biology 1st Edition by Jane M Carlton, Susan L Perkins, Kirk W Deitsch ISBN 1908230762 9781908230768

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ISBN 10: 1908230762
ISBN 13: 9781908230768
Author: Jane M Carlton, Susan L Perkins, Kirk W Deitsch

Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionised research in this area. In this book, expert authors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued.

Topics include: Plasmodium taxonomy and phylogeny; the apicomplexan genomic landscape; the ‘art’ of sequencing Plasmodium genomes; diversity of Plasmodium falciparum and Plasmodium vivax genomes; Plasmodium functional genomics; Plasmodium experimental genetic crosses; P. falciparum epigenetic modification and transcriptional regulation; Plasmodium invasion of host red blood cells; protein export and trafficking by malaria parasites; Plasmodium-mosquito vector interactions; and a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book is essential reading for every researcher working with malaria parasites and related organisms, from the PhD student to the experienced scientist, and is a recommended text for all parasitologists.

Malaria Parasites Comparative Genomics Evolution and Molecular Biology 1st Table of contents:

1. Introduction to Malaria Parasites

• 1.1 Overview of Malaria and Its Global Impact

• 1.2 Biology and Life Cycle of Plasmodium Species

• 1.3 Historical Perspectives and Research Milestones

2. Genomic Architecture of Malaria Parasites

• 2.1 Genome Sequencing and Assembly

• 2.2 Comparative Genomics Across Plasmodium Species

• 2.3 Gene Content, Organization, and Variation

3. Molecular Evolution of Malaria Parasites

• 3.1 Evolutionary Origins and Phylogenetics

• 3.2 Mechanisms of Genetic Diversity and Adaptation

• 3.3 Drug Resistance Evolution

4. Host-Parasite Interactions

• 4.1 Molecular Basis of Infection and Immune Evasion

• 4.2 Host Specificity and Adaptation

• 4.3 Molecular Determinants of Virulence

5. Functional Genomics and Gene Regulation

• 5.1 Transcriptomics and Proteomics

• 5.2 Epigenetic Regulation

• 5.3 Non-coding RNAs and Regulatory Networks

6. Molecular Biology Techniques in Malaria Research

• 6.1 Genetic Manipulation and Transfection

• 6.2 Functional Characterization of Genes

• 6.3 High-Throughput Screening Approaches

7. Implications for Drug and Vaccine Development

• 7.1 Target Identification and Validation

• 7.2 Molecular Markers of Drug Resistance

• 7.3 Vaccine Candidates and Immune Targets

8. Future Directions and Emerging Technologies

• 8.1 Single-Cell Genomics and Systems Biology

• 8.2 CRISPR and Genome Editing in Malaria Parasites

• 8.3 Integrative Approaches to Malaria Control

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Tags: Jane M Carlton, Susan L Perkins, Kirk W Deitsch, Malaria Parasites, Genomics Evolution, Molecular Biology