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Nucleosomes Histones Chromatin Part A 1st Edition by Carl Wu, C David Allis ISBN 0123919401 9780123919403

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Nucleosomes Histones Chromatin Part A 1st Edition Carl Wu And C. David Allis (Eds.) Digital Instant Download

Author(s): Carl Wu and C. David Allis (Eds.)
ISBN(s): 9780123919403, 0123919401
Edition: 1
File Details: PDF, 7.68 MB
Year: 2012
Language: english
SKU: EB-4548592 Category: Tag:

Nucleosomes Histones Chromatin Part A 1st Edition by Carl Wu, C David Allis – Ebook PDF Instant Download/Delivery: 0123919401, 9780123919403
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ISBN 10: 0123919401 
ISBN 13: 9780123919403
Author: Carl Wu, C David Allis

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 2 volumes covering nucleosomes, histones and chromatin, it has chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins.

  • Continues the legacy of this premier serial by containing quality chapters authored by leaders in the field
  • The first of 2 volumes covering nucleosomes, histones and chromatin
  • Chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins

Nucleosomes Histones Chromatin Part A 1st Table of contents:

  • Introduction to Chromatin Structure
    1.1. Overview of Chromatin
    1.2. Historical Perspectives
    1.3. Chromatin Organization Levels

  • Histone Proteins: Types and Functions
    2.1. Core Histones: H2A, H2B, H3, H4
    2.2. Linker Histone H1 and its Role
    2.3. Histone Variants and Their Biological Significance

  • Nucleosome Core Particle
    3.1. Nucleosome Assembly and Structure
    3.2. DNA-Histone Interactions
    3.3. Dynamics and Stability of Nucleosomes

  • Posttranslational Modifications of Histones
    4.1. Types of Modifications (Acetylation, Methylation, Phosphorylation, etc.)
    4.2. Enzymes Involved in Histone Modifications
    4.3. Functional Impact on Chromatin and Gene Expression

  • Chromatin Remodeling Complexes
    5.1. ATP-Dependent Remodeling Mechanisms
    5.2. Major Families of Remodeling Complexes
    5.3. Roles in Transcription and DNA Repair

  • Techniques to Study Nucleosomes and Chromatin
    6.1. Chromatin Immunoprecipitation (ChIP)
    6.2. MNase Digestion Assays
    6.3. Atomic Force Microscopy and Cryo-EM

  • Chromatin and Cellular Processes
    7.1. Chromatin in DNA Replication and Repair
    7.2. Chromatin and Cell Cycle Regulation
    7.3. Epigenetic Inheritance and Memory

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Tags: Carl Wu, C David Allis, Nucleosomes Histones, Chromatin