Statins The HMG CoA Reductase Inhibitors in Perspective 2nd Edition by Allan Gaw MD PhD , Christopher J Packard MRCPath DSc , James Shepherd MB ChB PhD FRCPath FRCP ISBN 1841842923 978-1841842929

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Product details: 

ISBN 10: 1841842923

ISBN 13: 978-1841842929

Author: Allan Gaw MD PhD , Christopher J Packard MRCPath DSc , James Shepherd MB ChB PhD FRCPath FRCP 

What is a statin? It is the most powerful lipid-lowering agent yet produced. Its main action is to lower the low-density lipoprotein (LDL) cholesterol level, thereby reducing the overall cholesterol level in the blood. In this new edition of this popular book, the authors examine the existing and emerging statins and their beneficial effectiveness in reducing serum cholesterol. New chapters cover combination therapy in lipid-lowering, new ‘Megatrials’ (HPS and PPP) and the PROSPER study. Also presented are the effects of statins on non-vascular conditions such as osteoporosis, cancer, dementia and diabetes.

Table of contents: 

Hyperlipidaemia as a Risk Factor for Coronary Heart Disease

Lipid Control in the Pre-Statin Era

The Discovery and Development of the Statins

Comparative Chemistry, Pharmacology and the Mechanism of Action of the Statins

Ancillary Benefits of the Statins

Angiographic and IVUS Techniques Evaluating Progression and Regression of Coronary Atherosclerosis: Statin Intervention Trials in Perspective

The Scandanavian Simvastatin Survival Study (4S)

Primary Prevention of Coronary Heart Disease with Statins

The CARE (Cholesterol and Recurrent Events) Trial: The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

The LIPID (Long-term Intervention with Pravastatin in Ischemic Disease) Study: Results and Implications for Clinical Practice

Mega-trials: the Prospective Pravastatin Pooling Project (PPP) and the Heart Protection Study (HPS)

The Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)

Combination Therapy with Statins

Guidelines for Clinical Use of the Statins

The Cost-effectiveness of Statin Use

Unanswered Questions About the Use of Statins

Statin Therapy for the 21st Century

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Tags: Allan Gaw MD PhD, Christopher J Packard MRCPath DSc, James Shepherd MB ChB PhD FRCPath FRCP, HMG CoA Reductase