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Animal Models of Movement Disorders Volume II 1st Edition by Miriam A Hickey, Marie Francoise Chesselet, Emma L Lane, Stephen B Dunnett ISBN 1617793019 9781617793011

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Animal Models of Movement Disorders Volume II 1st Edition Miriam A. Hickey Digital Instant Download

Author(s): Miriam A. Hickey, Marie-Françoise Chesselet (auth.), Emma L. Lane, Stephen B. Dunnett (eds.)
ISBN(s): 9781617793011, 1617793019
Edition: 1
File Details: PDF, 11.03 MB
Year: 2011
Language: english
SKU: EB-2452878 Category: Tags: , , ,

Animal Models of Movement Disorders Volume II 1st Edition by Miriam A Hickey, Marie Françoise Chesselet, Emma L Lane, Stephen B Dunnett – Ebook PDF Instant Download/Delivery: 1617793019, 9781617793011
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Product details:

ISBN 10: 1617793019 
ISBN 13: 9781617793011
Author: Miriam A Hickey, Marie Françoise Chesselet, Emma L Lane, Stephen B Dunnett

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition.Animal Models of Movement Disordersintroduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such asdrosophilaandc. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior.Volume IIof this detailed collection contains sections on the basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems, as well as spinal cord systemsprehensive and meticulous,Animal Models of Movement Disordersserves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.

Animal Models of Movement Disorders Volume II 1st Table of contents:

  1. Introduction to Animal Models of Movement Disorders
    Overview of movement disorders and the role of animal models in research.

  2. Genetic Models of Parkinson’s Disease
    Description of transgenic and knockout models mimicking Parkinson’s pathology.

  3. Toxin-Induced Models of Parkinsonism
    Use of neurotoxins like MPTP, 6-OHDA, and rotenone in animal studies.

  4. Animal Models of Huntington’s Disease
    Genetic and pharmacological approaches to model Huntington’s disease.

  5. Models of Dystonia
    Animal models replicating the clinical and pathophysiological features of dystonia.

  6. Rodent Models of Essential Tremor
    Behavioral and pharmacological characterizations in rodents.

  7. Models of Ataxia
    Genetic and lesion models used to study cerebellar ataxias.

  8. Animal Models of Restless Legs Syndrome
    Exploring sensorimotor and behavioral changes in relevant models.

  9. Pharmacological Testing and Behavioral Assessments
    Techniques for evaluating motor function and drug efficacy in models.

  10. Neuroimaging and Electrophysiology in Animal Models
    Tools for assessing brain changes and neural activity.

  11. Future Directions in Movement Disorder Modeling
    Emerging technologies and new genetic tools.

  12. Appendix and Methodological Considerations
    Standard protocols and ethical considerations.

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Tags: Miriam A Hickey, Marie Francoise Chesselet, Emma L Lane, Stephen B Dunnett, Animal Models