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Nonalcoholic Fatty Liver Disease NAFLD 1st Edition by Tatjana Abel, Gabriella Lengyel ISBN 1681084651 9781681084657

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Nonalcoholic Fatty Liver Disease NAFLD 1st Edition Tatjana Ábel Digital Instant Download

Author(s): Tatjana Ábel; Gabriella Lengyel
ISBN(s): 9781681084657, 1681084651
Edition: 1
File Details: PDF, 4.59 MB
Year: 2017
Language: english
SKU: EB-51609560 Category: Tags: ,

Nonalcoholic Fatty Liver Disease NAFLD 1st Edition by Tatjana Abel, Gabriella Lengyel – Ebook PDF Instant Download/Delivery: 1681084651, 9781681084657
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Product details:

ISBN 10: 1681084651 
ISBN 13: 9781681084657
Author: Tatjana Abel, Gabriella Lengyel

Non-alcoholic fatty liver disease (NAFLD) is a common cause of elevated liver enzymes and chronic liver disease in Western countries. NAFLD is characterized by elevated liver enzymes in the absence of alcohol consumption and secondary causes of liver disease. It is an independent predictor of future risk of cardiovascular diseases, type 2 diabetes and metabolic syndrome (hypertension, abdominal obesity, dyslipidemia, glucose intolerance). This book is a quick reference guide for medical students and professionals about NAFLD. Readers will find a summary of epidemiology, clinical features, diagnosis, imaging techniques, histopathology, and disease management. The book also presents information about NAFLD linked with hepatocellular carcinoma and guidelines for treating NAFLD in pediatric patients. Each chapter presents information in a simple, structured manner making this text an ideal handbook for supplementing hepatology modules in medical curricula.

Nonalcoholic Fatty Liver Disease NAFLD 1st Table of contents:

PREVALENCE OF NAFLD AND NASH
Liver Biopsy and Autopsy Studies
Ultrasound (US)
Magnetic Resonance Imaging (MRI)
Non-invasive Biomarker for Fibrosis: Fibrotest
Elevation in Liver Enzymes and Combinations of Clinical Variables
RISK FACTORS
Age
Gender
Race, Ethnicity and Gene Variants
Metabolic Disorders
Polycystic Ovarian Syndrome (PCOS)
Hepatitis C Virus (HCV)
NATURAL HISTORY
BRIEFLY ON NAFLD AND CARDIOVASCULAR DISEASE (CVD)
SUMMARY
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Clinical Manifestations and Diagnosis of NAFLD
István Tornai*
INTRODUCTION
Extrahepatic Complications of NAFLD
Cardiovascular Disorders and NAFLD
Chronic Kidney Disease and NAFLD
Osteoporosis and NAFLD
Endocrinopathies
Hypothyroidism
Polycystic Ovarian Syndrome
Obstructive Sleep Apnea Syndrome
Carcinogenesis and NAFLD
Colorectal Cancer
Progression of Liver Disease in NAFLD
Patients with Risk of Progression
Cirrhotic NASH
Alcohol and NAFLD
NASH in Lean Patients
Diagnosis of NAFLD
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Imaging of NAFLD
Zoltán Harmat* and Omar Giyab
INTRODUCTION
IMAGING MODALITIES
Ultrasound
Sonoelastography
Computed Tomography
Magnetic Resonance Imaging
Chemical Shift Imaging
Fast SE Imaging
MR Spectroscopy
MR Elastography
CONCLUSION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Histopathological Changes of NAFLD
Peter Nagy*
INTRODUCTION
GENERAL HISTOLOGICAL FEATURES OF NAFLD
THE ROLE AND VALUE OF LIVER BIOPSY IN THE DIAGNOSIS AND TREATMENT OF NAFLD PATIENTS
HISTOLOGICAL CHARACTERISTICS OF NAFLD
Steatosis
Inflammation
Hepatocellular Injury, Ballooning
Liver Fibrosis and Ductular Reaction
NAFLD-RELATED CIRRHOSIS
NAFLD AND HEPATOCELLULAR CARCINOMA
PEDIATRIC NAFLD
HISTOLOGICAL SCORING OF NAFLD
DIFFERENTIAL DIAGNOSTIC CONSIDERATIONS
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Pathophysiology of NAFLD
Gabriella Par*
INTRODUCTION
EXTRAHEPATIC AND INTRAHEPATIC MECHANISMS IN NAFLD
Extrahepatic Mechanisms
Intrahepatic Mechanisms
Enzymes
Transcription Factors
GENETICS AND EPIGENETIC EFFECTS
Genetics
Epigenetic Effects
ADIPOKINES
OXIDATIVE AND ENDOPLASMIC RETICULUM STRESS
INSULIN RESISTANCE (IR)
OBESITY
APOPTOSIS
HEPATOCYTE SENESCENCE
IMMUNE RESPONSE
Toll-like Receptors
Th17 Response
FIBROSIS, HEPATOCYTE BALLOONING, HEDGEHOG PATHWAY AND VITAMIN E IN NASH
Hepatocyte Ballooning
Hedgehog Pathway
Vitamin E
SUMMARY
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Metabolic Diseases and NAFLD
Tatjana Ábela,b,*
INTRODUCTION
OBESITY
TYPE 2 DIABETES
LIPID DISORDERS
HYPERTENSION
METABOLIC SYNDROME
CONCLUDING REMARKS
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Management of NAFLD
Krisztina Hagymási* and Gabriella Lengyel
INTRODUCTION
Treatment
Reduction of Body Weight
Diet
Physical Activity
Pharmacotherapy
Improving Insulin Sensitivity
Reduction of Lipid Levels
Antioxidants
Ursodeoxycholic Acid
Liver Transplantation
CONCLUDING REMARKS
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma
György Baffy*
INTRODUCTION
RISK FACTORS OF HCC IN NAFLD
Obesity and Diabetes
NAFLD with Advanced Fibrosis
NAFLD without Advanced Fibrosis
Concurrent Chronic Liver Disease
MOLECULAR MECHANISMS OF HCC DEVELOPMENT IN NAFLD
Oncogenic Pathways in Cirrhosis
Genetic Variability and Predisposition to NAFLD-HCC
Adipose Expansion and Adipokine Imbalance
Lipotoxicity
Insulin Resistance
Altered Gut Microbiota
MicroRNAs and Hepatocarcinogenesis
DIAGNOSIS OF NAFLD-HCC
Clinical Presentation
Biomarkers of HCC Development in NAFLD
RISK REDUCTION STRATEGIES FOR HCC COMPLICATING NAFLD
Screening and Surveillance
Lifestyle Measures
Insulin-sensitizing Agents
Emerging Opportunities for Chemoprevention
PERSPECTIVES
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Non-Alcoholic Fatty Liver Disease in the Pediatric Population
Zsuzsanna Almássy*
INTRODUCTION
EPIDEMIOLOGY, PATHOGENESIS
NAFLD AND CVD IN CHILDREN
RISK AND DEVELOPMENT OF NAFLD
DEVELOPMENT OF NAFLD
DIAGNOSIS AND PROGNOSIS
THERAPY AND FOLLOW-UP OF PATIENTS
CONCLUSION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS

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Tatjana Abel,Gabriella Lengyel,Nonalcoholic,Disease NAFLD