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Thrombosis and Cancer 1st Edition by Gilles Lugassy, Anna Falanga, Ajay K Kakkar, Frederick R Rickles ISBN 1841842877 9781841842875

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Thrombosis and Cancer 1st Edition Gilles Lugassy Digital Instant Download

Author(s): Gilles Lugassy, Anna Falanga, Ajay K Kakkar, Frederick R. Rickles
ISBN(s): 9781841842875, 1841842877
Edition: 1
File Details: PDF, 1.27 MB
Year: 2003
Language: english
SKU: EB-1379646 Category: Tags: , , ,

Thrombosis and Cancer 1st Edition by Gilles Lugassy, Anna Falanga, Ajay K Kakkar, Frederick R Rickles – Ebook PDF Instant Download/Delivery: 1841842877, 9781841842875
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Product details:

ISBN 10: 1841842877 
ISBN 13: 9781841842875
Author: Gilles Lugassy, Anna Falanga, Ajay K Kakkar, Frederick R Rickles

This text provides comprehensive and timely coverage of the current knowledge of cancer-associated thrombosis, its pathogenesis, clinical features, prevention, and therapy. It specifically addresses the relationship between hemostatic systems and cancer, thus providing a unique and much needed focus. All of the contributors are acknowledged specialists in their fields and have experience conducting large clinical trials in oncology and thrombosis. Their discussions cover all aspects of the topic, from long-term complications to cancer surgery. It will be of interest to general practitioners, internists, oncologists, hematologists, and all physicians involved in the management of cancer patients.

Thrombosis and Cancer 1st Table of contents:

Chapter 1: Thrombosis and Cancer: A Short History of Trousseau’s Syndrome

  • Historical Background

  • Definitions

  • Patients With Known Cancer At Time of VTE

  • Concomitant Diagnosis of VTE and Cancer

  • Diagnosis of Cancer After VTE

  • Detection of Occult Cancer By Extensive Screening

  • Conclusion

  • References

Chapter 2: Pathogenesis of Thrombosis in Cancer

  • Introduction

  • Pathogenetic Mechanisms

  • Cancer-Cell Interaction With Blood Cells

  • Cancer-Cell Procoagulants, Fibrinolysis Proteins, and Cytokines

  • Tumor-Cell Damage

  • Summary and Conclusions

  • References

Chapter 3: Platelets and Cancer

  • Introduction

  • Thrombocytosis and Thrombocytopenia in Cancer Patients

  • Platelets, Cancer Metastasis, and Cancer Growth

  • Conclusions

  • References

Chapter 4: The Role of Blood Clotting in Tumor Metastasis: A Case for Tissue Factor

  • Introduction

  • The Blood-Clotting Scheme and Cancer Procoagulants

  • TF and Tumor Metastasis

  • Mechanisms of Tumor Metastasis Modulation by TF

  • TF, Protease-Activated Receptors (PAR), and Tumor Metastasis

  • TF and Angiogenesis

  • Conclusions

  • Acknowledgments

  • References

Chapter 5: The Fibrinolytic System in Cancer

  • Basic Mechanisms in Fibrinolysis

  • Fibrin and Cancer

  • Fibrinolytic Activities of Cancer Cells

  • Clinical and Prognostic Significance of the Plasminogen Activator System in the Cancer Patient

  • Hematological Malignancies

  • The Tumor-Associated Plasminogen Activation System: A Possible Target for Anticancer Therapy

  • References

Chapter 6: Tumor Angiogenesis and Blood Coagulation

  • Abbreviations

  • Introduction

  • Tissue Factor (TF)

  • Thrombin

  • Fibrin

  • Therapeutic Applications

  • Thrombotic Complications of Antiangiogenic Agents

  • Concluding Remarks

  • Acknowledgment

  • References

Chapter 7: Risk of Cancer in Patients Presenting With Venous Thromboembolism

  • Introduction

  • Historical Background

  • Pathogenesis of VTE in Cancer

  • Present Knowledge

  • Clinical Spinoff

  • Concomitant Diagnosis of Cancer

  • The SOMIT Study

  • Future Perspectives

  • Prognosis of Patients With Cancer and VTE

  • References

Chapter 8: Thrombotic Complications of Overt Cancer

  • Frequency of Thromboembolism in Untreated Cancer Patients

  • Clinical Characteristics of Thrombosis in Cancer Patients

  • References

Chapter 9: Systemic Microangiopathies in the Cancer Patient

  • Introduction

  • Clinical Presentation and Incidence

  • Pathogenesis of Coagulation Activation in Cancer Patients

  • Thrombotic Microangiopathy in Cancer and Chemotherapy

  • A Pivotal Role of Endothelium in Cancer-Related and Chemotherapy-Induced Thrombotic Microangiopathy?

  • Effects of Cancer-Related and Chemotherapy-Induced Endothelial Damage on Primary Hemostasis and Von Willebrand Factor

  • Effects of Chemotherapy-Induced Endothelial Damage on Coagulation

  • Effects of Cancer-Related and Chemotherapy-Induced Endothelial Damage on Fibrinolysis

  • Conclusion

  • References

Chapter 10: Thrombophilia and the Risk of Venous Thromboembolism in Cancer

  • Introduction

  • APC Resistance and Factor V Leiden (FVL)

  • Thrombophilia Polymorphisms

  • The Natural Anticoagulants

  • Antiphospholipid Antibodies (APA)

  • Hyperhomocysteinemia (HHC) and Cancer

  • Summary

  • References

Chapter 11: Long-Term Thrombotic Complications in Cancer-Treated Patients: The Problem of Recurrent Venous Thromboembolism

  • Introduction

  • Risk Factors Predisposing to Recurrent VTE

  • Diagnosis of Recurrent VTE

  • Treatment of VTE

    • Low-Molecular-Weight Heparin or Unfractionated Heparin

    • Warfarin Treatment

  • Recurrent VTE in Patients With Cancer

  • Long-Term Low-Molecular-Weight Heparin Treatment

  • Inferior Vena Cava Filters in Patients With Recurrent VTE

  • Conclusions

  • References

Chapter 12: Prevention of Cancer-Associated Thrombosis: An Overview

  • Surgical Patients

  • Medical Patients

  • Catheter-Related Thrombosis

  • Summary

  • References

Chapter 13: Thromboprophylaxis in Cancer Surgery

  • Introduction

  • The Pathogenesis of Thrombosis

  • Epidemiology

  • Available Drugs

  • VTE Prevention

  • Prevention of Secondary Recurrence

  • Antithrombotic Therapy and Cancer Survival

  • Conclusions

  • References

 

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Tags: Gilles Lugassy, Anna Falanga, Ajay K Kakkar, Frederick R Rickles, Thrombosis, Cancer