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Principles and Applications of Asymmetric Synthesis 1st Edition by Guo Qiang Lin, Yue Ming Li, Albert SC Chan ISBN 0471465240 9780471465249

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Principles and Applications of Asymmetric Synthesis 1st Edition Guo-Qiang Lin Digital Instant Download

Author(s): Guo-Qiang Lin, Yue-Ming Li, Albert S. C. Chan,
ISBN(s): 9780471465249, 0471465240
Edition: 1
File Details: PDF, 28.31 MB
Year: 2001
Language: english
SKU: EB-1899166 Category: Tags: , ,

Principles and Applications of Asymmetric Synthesis 1st Edition by Guo Qiang Lin, Yue Ming Li, Albert SC Chan – Ebook PDF Instant Download/Delivery: 0471465240, 9780471465249 
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ISBN 10: 0471465240
ISBN 13: 9780471465249
Author: Guo Qiang Lin, Yue Ming Li, Albert SC Chan

Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one-volume resource for the convenience of practicing scientists and students.
Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as well as catalytic asymmetric reactions. The first chapter reviews the basic principles, common nomenclature, and analytical methods, and the remainder of the book is organized according to reaction type. The text examines such topics as:

  • Carbon-carbon bond formations involving carbonyls, enamines, imines, and enolates
  • Asymmetric C-O bond formations including epoxidation, dihydroxylation, and aminohydroxylation
  • Asymmetric synthesis using the Diels-Alder reaction and other cyclizations
  • Applications to the total synthesis of natural products
  • Use of enzymes in asymmetric synthesis

Practicing chemists in the pharmaceutical, fine chemical, and agricultural professions as well as graduate students will find that Principles and Applications of Asymmetric Synthesis affords comprehensive and current coverage.

Principles and Applications of Asymmetric Synthesis 1st Table of contents:

Chapter 1: Fundamentals of Stereochemistry and Chirality

1.1 chirality and molecular symmetry
1.2 stereoisomerism and stereogenic centers
1.3 enantiomers and diastereomers
1.4 optical activity and chiroptical techniques
1.5 conformational analysis and stereochemical control

Chapter 2: Mechanistic Principles of Asymmetric Reactions

2.1 chiral reagents and chiral auxiliaries
2.2 transition state models for stereocontrol
2.3 substrate-directed asymmetric induction
2.4 reagent-controlled asymmetric synthesis
2.5 kinetic versus thermodynamic control in chiral outcomes

Chapter 3: Catalytic Asymmetric Synthesis

3.1 introduction to chiral catalysts
3.2 organocatalysis and small-molecule strategies
3.3 metal-catalyzed asymmetric reactions
3.4 enzymatic and biocatalytic asymmetric synthesis
3.5 chiral Lewis acids and asymmetric hydrogenation

Chapter 4: Asymmetric Inductions in Carbon–Carbon Bond Formation

4.1 aldol reactions with asymmetric control
4.2 asymmetric Michael addition reactions
4.3 enantioselective alkylations and allylation
4.4 proline-based and secondary amine organocatalysts
4.5 stereoselective carbonyl additions

Chapter 5: Asymmetric Heteroatom Chemistry

5.1 enantioselective oxidations and reductions
5.2 asymmetric epoxidation and dihydroxylation
5.3 asymmetric amination and hydrazination reactions
5.4 enantioselective C–H functionalization
5.5 chiral catalysts in heteroatom transfers

Chapter 6: Total Synthesis of Natural Products via Asymmetric Strategies

6.1 case studies in asymmetric total synthesis
6.2 synthetic design using chiral pool building blocks
6.3 relay strategies using sequential asymmetric steps
6.4 cascade and tandem reactions for stereoselectivity
6.5 multistep synthesis with high enantioselectivity

Chapter 7: Asymmetric Synthesis in Pharmaceutical Development

7.1 chiral drugs and regulatory requirements
7.2 scalable asymmetric processes in industry
7.3 process development and optimization
7.4 analytical methods for enantiomeric purity
7.5 case studies: chiral drug molecules

Chapter 8: Emerging Trends and Future Directions in Asymmetric Synthesis

8.1 green chemistry and sustainable asymmetric methods
8.2 flow chemistry and process intensification
8.3 photochemical and electrochemical asymmetric synthesis
8.4 computational design in asymmetric catalysis
8.5 machine learning for catalyst and reaction prediction

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Tags: Guo Qiang Lin, Yue Ming Li, Albert SC Chan, Principles, Asymmetric