Inflammatory bowel disease crossroads of microbes epithelium and immune systems Novartis Foundation Symposia 1st Edition by Jamie Goode ISBN 978-0470668061 0470668061

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Product details: 

ISBN 10:  0470668061 

ISBN 13: 978-0470668061

Author: Jamie Goode 
Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as:

• Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival
• The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy
• The progress towards the identification of susceptibility genes and phenotype-determining genes
• The pharmacogenetics of IBD
• Mucosal immunology and therapeutic strategies stemming therefrom

Table of contents: 

CHAIR’S INTRODUCTION

1. Derek Jewell – Chair’s Introduction

GENETIC SUSCEPTIBILITY AND PHENOTYPE

2. John D. Rioux – Progress towards Identifying Inflammatory Bowel Disease Susceptibility Genes

3. Discussion

4. T. Ahmad – Phenotype-Determining Genes in Inflammatory Bowel Disease

5. Discussion

6. Dermot Kelleher, Richard Farrell and Ross McManus – Pharmacogenetics of Inflammatory Bowel Disease

7. Discussion

MICROBIAL AND MUCOSAL FACTORS

8. G. T. Macfarlane, E. Furrie and S. Macfarlane – Bacterial Milieu and Mucosal Bacteria in Ulcerative Colitis

9. Discussion

10. Y. R. Mahida and R. N. Cunliffe – Defensins and Mucosal Protection

11. Discussion

12. W. E. W. Roediger – Intestinal Mycoplasma in Crohn’s Disease

13. Discussion

MICROBIOTA-BASED INTERVENTIONS

14. John H. Cummings and San Choon Kong – Probiotics, Prebiotics and Antibiotics in Inflammatory Bowel Disease

15. Discussion

EPITHELIAL BARRIER AND CELL SURVIVAL

16. Andrei I. Ivanov, Asma Nusrat and Charles A. Parkos –
    The Epithelium in Inflammatory Bowel Disease: Potential Role of Endocytosis of Junctional Proteins in Barrier Disruption

17. Discussion

18. Peter R. Gibson – Apoptosis or Necrosis: Colonic Epithelial Cell Survival

19. Discussion

INTESTINAL PERMEABILITY AND GENETIC CONTROL

20. Ken Takeuchi, Laurence Maiden and Ingvar Bjarnason – Genetic Aspects of Intestinal Permeability in Inflammatory Bowel Disease

21. Discussion

ANIMAL MODELS AND PATHOGENESIS

22. Fiona Powrie and Holm Uhlig – Animal Models of Intestinal Inflammation: Clues to the Pathogenesis of Inflammatory Bowel Disease

23. Discussion

IMMUNE CELL TRAFFICKING AND REGULATION

24. Holm H. Uhlig, Christian Mottet and Fiona Powrie – Homing of Intestinal Immune Cells

25. Discussion

THERAPEUTIC STRATEGIES

26. S. Ghosh – Anti-TNF Therapy in Crohn’s Disease

27. Discussion

CONCLUDING SECTION

28. Final Discussion

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Tags: Jamie Goode, Inflammatory bowel, disease crossroads