Uterine Cancer 1st Edition by David M Luesley, Frank Lawton, Andrew Berchuck ISBN 0824759516 9780824759513

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ISBN 10: 0824759516 
ISBN 13: 9780824759513
Author: David M. Luesley, Frank Lawton, Andrew Berchuck

Uterine Cancer 1st Table of contents:

1. Epidemiology
Incidence and Mortality
Cancer Subtypes
Risk Factors For Endometrial Cancer
Menstrual Factors
Reproductive Factors
Hormone Replacement Therapy
Oral Contraceptives
Body Mass
Diabetes and Hypertension
Smoking
Diet, Alcohol, and Exercise
Genetic Risk Factors
References

2 Screening in Endometrial Cancer
What Does Cancer Screening Actually Mean?
Cancer Screening Traps
In Non-Randomized Trials
Lead Time Bias
Length Bias
Overdiagnosis Bias
Selection Bias
In Randomized Trials
Internal Validity—Contamination
Internal Validity—Dilution
External Validity—Representativity
Screening For Endometrial Cancer?
Screening Tests For Endometrial Cancer
What Could Be Gained By Screening For Endometrial Cancer?
The Natural Course of Endometrial Cancer—Premalignant Conditions?
Risk Groups
Preliminary Screening Trials
Conclusions
References

3. Pathology of Endometrial Hyperplasia and Neoplasia
Introduction
Classification of Endometrial Carcinomas
Types 1 and 2 Carcinoma
Endometrioid Carcinoma
Variants of Endometrioid Carcinoma
Secretory Carcinoma
Villoglandular Carcinoma
Ciliated Carcinoma
Endometrioid Carcinoma with Squamous Differentiation
Other Recently Described Variants
Mucinous Carcinoma
Serous Carcinomas
Clear Cell Carcinoma
Mixed Carcinomas
Undifferentiated Carcinoma
Other Rare Types of Endometrial Carcinoma
Tumors Metastatic to the Endometrium
Pathologic Prognostic Factors for Endometrial Carcinomas
Stage
Grade
Histological Type
Myometrial Invasion
Cervical Involvement
Peritoneal Cytology
Lymph Node Metastases
Concepts in Early Endometrial Neoplasia
Endometrial Hyperplasia
Endometrial Intraepithelial Neoplasia
Endometrial Intraepithelial Carcinoma
Important Issues in Interpretation of Endometrial Biopsies
References

4. Pathology of Uterine Sarcoma
Introduction
Staging of Uterine Sarcomas
Endometrial Stromal Sarcoma
High-Grade Stromal Sarcoma and the Controversies in Classification
Endometrial Stromal Sarcoma— “Low Grade”
Gross Pathology
Microscopic Pathology
Diagnosis of Endometrial Stromal Sarcoma on Curettage Material
Immunohistochemistry of Uterine Sarcomas
Hormonal Aspects of Stromal Sarcomas
Leiomyosarcoma
Gross Appearance
Histological Features
Myxoid Leiomyosarcoma
Epithelioid Leiomyosarcoma
Carcinosarcoma: A Metaplastic Carcinoma or Sarcoma?
Pure Sarcomas
Tamoxifen and Its Role in Uterine Sarcoma
References

5. The Molecular Genetics of Endometrial Cancer
Introduction
Somatic Genetic Alterations
Oncogenes
RAS Genes
ERBB2
β-Catenin
Tumor Suppressor Genes
p53
PTEN
DNA Repair Genes
Hereditary Endometrial Cancer
Epigenetics in Endometrial Carcinoma
MLH1 Methylation
APC Methylation
Methylation Epigenetic Silencing of Other Genes
Hormones as an Epigenetic Phenomena
Microarray
Summary of the Molecular Biology of Endometrial Cancer
References

6. Clinical Presentation and Investigation: The “One-Stop”Clinic, Endometrial Sampling, Hysteroscopy, Vaginal Ultrasound
Introduction
Investigations
Blind Endometrial Biopsy
Transvaginal Ultrasound
Saline Infusion Sonohysterography
Outpatient Hysteroscopy
The Rapid Access Clinic
Conclusion
References

7. Imaging Endometrial Cancer
Magnetic Resonance Imaging
References

8. Surgery for Uterine Cancer
Endometrial Cancer
Prognostic Factors That May Help Determine the Appropriate Surgery For Endometrial Cancer
Age
Histologic Type
Tumor Grade and Depth of Myometrial Invasion
Tumor Size
Peritoneal Cytology
Other Prognostic Factors
Diagnosis
Preoperative Work Up
The Surgical Procedure
Stage II Endometrial Cancer
Clinical Stage III Disease
Stage IV Endometrial Cancer
Recurrent Endometrial Cancer
Endometrial Cancer Found After Routine Hysterectomy
Who Should Perform Surgery?
Uterine Sarcomas
Summary
References

9. Risk Factors and the Role of Radiotherapy in the Treatment of Endometrial Cancer
History of Radiation
Staging and Prognostic Factors
Stage I Disease
Adjuvant Therapy
Adjuvant Brachytherapy Alone
Treatment of Recurrence
Primary Treatment with Radical Radiation
Stage II Disease
Stage III and IV Disease
Stage IIIA
Stage IIIΒ
Stage IIIC
Palliative Radiotherapy
Uterine Papillary Serous Carcinoma
Uterine Sarcomas
Irradiation Technique and Dose
Radiotherapy Toxicity
Conclusions
References

10. Chemotherapy for Uterine Cancer
Introduction
Endometrioid Adenocarcinoma
Single Agent Therapy
Combination Regimens
Chemotherapy vs. Whole Abdominal Radiotherapy
Adjuvant Chemotherapy
Conclusion
Serous Carcinoma
Adjuvant Therapy
Uterine Sarcomas
Carcinosarcoma
Single Agents
Combination Chemotherapy
Leiomyosarcoma
Single Agents
Combination Therapy
Adjuvant Chemotherapy
Conclusions
References

11. Minimal Access Surgery in Endometrial Cancer
Introduction
The Role of Vaginal Hysterectomy in the Management of Endometrial Cancer
Laparoscopic-Assisted Vaginal Hysterectomy (LAVH)
Laparoscopic Lymphadenectomy
Application if LAVH and Lymphadenectomy for Endometrial Cancer
Complications of Laparoscopy
Clinical Outcome of Laparoscopic Versus Open Abdominal Surgical Approach To Management of Endometrial Cancer
Cost Benefit of Laparoscopic Surgery
Contraindications To Laparoscopic Surgery For Treatment of Endometrial Cancer
Setting Up For Laparoscopic Surgery
Laparoscopic Surgery
References

12. Follow-Up and Detection of Relapsed Disease in Uterine Cancer
Background
Patterns of Recurrence
Recurrence Rate
Time to Recurrence
Site of Recurrence
Recurrence Risk Groups
Prognosis After Recurrence
Detection and Surveillance
Surveillance Programs
Detection and Outcome
Conclusions
References

13. The Role of Surgery in Advanced and Relapsed Disease
Importance of Surgical Staging
Role of Radical Hysterectomy
Role of Primary Cytoreduction In Patients With Advanced Disease
Role of Secondary Cytoreduction In Patients With Relapsed Disease
Role of Pelvic Exenteration In Patients With Relapsed Disease
Conclusion
References

14. Endometrial Carcinoma and Hormone Replacement Therapy
Endometrial Cancer and Unopposed Estrogen Use
Vaginal Estrogen Treatment
The Addition of Progestogens
Tibolone and Endometrial Cancer Risk
Selective Estrogen Receptor Modulators (Serms)
Ert Use In Women With Previous Endometrial Carcinoma
Summary Points
References

15. Future Developments In Radiation Therapy For Endometrial Carcinoma
Reducing Indications For Pelvic Radiotherapy
The Role of Lymphadenectomy and Its Combination With Radiotherapy
The Increasing Use of Vaginal Brachytherapy Alone
The Use of Both Adjuvant Radiotherapy and Chemotherapy In High-Risk Disease
The Use of New Rt Techniques To Reduce Morbidity
Conclusions
References

16. Future Directions: Chemotherapy and Novel Agents for Uterine Cancer
Introduction
Adjuvant Chemotherapy
Combined Modality Therapy: Radiosensitizing Chemotherapy
Chemotherapy For Advanced Disease
Paclitaxel
Topotecan
Doxil®
Docetaxel
Oxaliplatin
Novel Agents
Targeting Growth Factors and Their Receptors
Trastuzumab (Herceptin®)
Gefitinib (Iressa®)
Erlotinib
Rapamycin
Targeting Angiogenesis
Conclusions
References

17. Combined Therapy in Uterine Cancer: Future Directions
Whole Abdominal Radiation Versus Chemotherapy
High-Risk Stage I Endometrial Carcinoma
Hormonal Therapy
The Gog Chemotherapy Trials In Endometrial Cancer
Alternative Chemotherapy Combinations
Current Gog Combined Radiation and Chemotherapy Trial
Combined Hormonal, Chemotherapy, and Radiation Therapy

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Tags: David M. Luesley, Frank Lawton, Andrew Berchuck, Uterine Cancer