Handbook of Nanotoxicology Nanomedicine and Stem Cell Use in Toxicology 1st Edition by Saura C. Sahu, Daniel A. Casciano – Ebook PDF Instant Download/Delivery: 1306685044, 9781306685047
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Product details:
ISBN 10: 1306685044
ISBN 13: 9781306685047
Author: Saura C. Sahu, Daniel A. Casciano
Handbook of Nanotoxicology Nanomedicine and Stem Cell Use in Toxicology 1st Table of contents:
Part One: Nanotoxicology
1: Testing Nanotoxicity: An Update of New and Traditional Methods
1 Introduction
2 The Point of View of the Regulatory Agencies
3 Reference Standards
4 Alternative Tests Implemented for Nanotoxicity Studies
6 In Vivo Toxicity
7 A Comprehensive Approach: Metabolomics
8 Computational Methods and In Silico Prediction of Toxicity
References
Further Reading
2: Considerations for In Vitro Nanotoxicity Testing
1 Introduction
2 Considerations Before Testing
3 Specific Factors in Assay Interference
4 Considerations for Assay Selection—Example: Viability Assays
5 Conclusion/Summary
Acknowledgments
Disclaimer
Related Articles
References
3: In Vivo Evaluation of Acute and Chronic Nanotoxicity
1 Introduction
2 Characterization of Nanomaterials
3 Routes of Exposure
4 Evaluation of Material Toxicity
5 Conclusion
References
Further Reading
4: Genotoxicity of Silver Nanoparticles*
1 Introduction
2 Genotoxicity Testings of Silver Nanoparticles
3 Mechanisms of genotoxicity of silver nanoparticles
4 Factors that Affect the Genotoxicity of Silver Nanoparticles
5 Perspectives of Genotoxicity Study on Silver nanoparticles
Related Articles
References
5: Immunotoxicology of Nanomaterials
1 Introduction
2 Main Text
3 Conclusion/Summary
Related Articles
References
6: Neurotoxicity of Nanoparticles
1 Introduction
2 Sources of Nanoparticles
3 Means of Entry of Nanoparticles into the Brain
4 Mechanisms Underlying Particulate-Related Neurological Damage
5 Relation to Neurological Disease
6 Summary
7 Conclusion
Related Articles
References
Further Reading
7: Nanoparticles and Plants: From Toxicity to Activation of Growth
1 Introduction
2 Uptake and Translocation of Nanomaterials Inside Plants
3 Risks Associated with Possible Entry of Nanomaterials into the Food Chain
4 Toxicity of Nanomaterials for Plants and Soil Microbial Community
5 Nanomaterials as Growth Regulators
6 Conclusion
Acknowledgments
References
8: Epigallocatechin-3-gallate (EGCG) in or on Nanoparticles: Enhanced Stability and Bioavailability of EGCG Encapsulated in Nanoparticles or Targeted Delivery of Gold Nanoparticles Coated with EGCG
1 Introduction
2 Enhanced Stability and Bioavailability of Egcg Encapsulated in Nanoparticles
3 Targeted Delivery of Radioactive Gold Nanoparticles to Tumors Via Egcg Coating
Acknowledgments
References
Part Two: Nanomedicine
9: Factors Affecting the Oral Bioavailability of Nanomaterials
1 Current Human Exposure
2 Barriers to GIT Particle Uptake and Important Determining Factors
3 Oral Bioavailability and Systemic Distribution
4 Special Population-Compromised Intestinal Health
5 Methods and Techniques
6 Limitations and Characterization Needs
Related Articles
References
10: Nanomedicine in Cancer Treatment
1 Introduction
2 Concepts and Principles of Cancer Treatment using Nanomaterials
3 Nanomaterials used for Cancer Therapy
5 Commercialized Nanoparticles for Cancer Treatment
6 Perspectives of Nanomedicine in Cancer Treatment
7 Conclusions
Acknowledgments
References
Further Reading
11: Nanomedicine in Diabetes: Using Nanotechnology in Prevention and Management of Diabetes Mellitus
1 Introduction
2 Nanodiagnostics in Diabetes—Blood Glucose Monitoring
3 Nanotechnology in Genomics and Potential Use in Diabetes Detection/Prevention
4 Examples of Nanomedicines in Diabetes
5 Nanotechnology and Artificial Pancreas
6 Concluding Remarks and Future Directions in Application of Nano in Diabetes
References
12: Inhalation Pathway as a Promising Portal of Entry: What Has to Be Considered in Designing New Nanomaterials for Biomedical Application?
1 Introduction
2 Anatomy of the Human Respiratory System
3 Nanomaterial–Lung Interactions
4 Bioavailability
5 Application Fields: Case Studies of Current Applications and Future Potential
6 Summary and Conclusion
Acknowledgment
References
13: Nanomedicine for the Brain and the Eye: Disease Management in Poorly Accessible Compartments of the Body
1 Introduction
2 Experimental Models for CNS and Eye
3 Nanotechnology can be Applied to Neuro-Oncology
4 Nanomaterials with High Versatility: Not only Oncology
5 The Nanomedicine for the Posterior Pole of the Eye
6 Conclusions
Related Articles
References
Further Reading
Part Three: Stem Cell Toxicology
14: Stem Cells in Toxicity Testing
1 Introduction
2 Developmental Toxicology
3 Suggested Modifications to the mest
4 Neurotoxicology and Developmental Neurotoxicology
5 Summary
Disclaimer
References
Further Reading
15: Human Stem-Cell-Derived Cardiomyocytes in Drug Discovery and Toxicity Testing
1 Introduction—Need for Human Cardiomyocytes in Drug Screening
2 Gene Delivery and Stable Genetic Modifications of Stem Cells
3 Generation of Human Cardiomyocytes
4 Human Pluripotent Stem-Cell-Derived Cardiac Progenitor Cells for Large Scale production
5 Reporter Systems Used to Follow Cardiac Differentiation
6 Cardiotoxicity of Drugs—Key Screening Systems for Drug Development
7 Application of Human Cardiomyocytes for Disease Models and Personalized Drug Development
8 Future Perspectives
Acknowledgments
Related Articles
References
16: Pluripotent Stem Cells as Tools to Assess Developmental Toxicity: Diversity Instead of Consolidation
1 Introduction
2 Embryonic Stem Cells
3 Embryonic Stem Cell Test
4 Model Organism
5 Conclusion
Acknowledgments
Related Articles
References
Further Reading
17: Impact of Various Nanosystems on Stem Cell Physiology
1 Introduction
2 Challenges Concerning the Toxicity of Nanomaterials
3 Physicochemical Parameters of the Nanoparticles Versus Toxicity
4 Toxicology Studies of Different Classes of Nanomaterials in Nonstem and Stem Cell Cultures
5 Conclusions
References
Further Reading
18: Predictive Mechanisms in Stem Cells: An In Vitro System-Based Method for Testing Carcinogenicity
1 Introduction
2 Gene Expression in Stem-Cell-Derived Hepatocytes
3 Gene Regulatory Responses to Chemically Induced Carcinogenicity
4 Identification of Predictive Pathways for Carcinogenicity
5 Conclusions and Outlook
Acknowledgments
References
Further Reading
19: Epigenetic Modifications and Stem Cell Toxicology: Searching for the Missing Link
1 Introduction
2 Dna Methylation
3 Histone Acetylation
4 Stem Cells
5 Stem Cells in Toxicology Testing
6 Conclusions
References
20: Epigenetic Modeling and Stem Cells in Toxicology Testing
1 Introduction
2 Epigenetics
3 Stem Cells
References
Further Reading
21: Use of Video Bioinformatics Tools in Stem Cell Toxicology
1 Introduction
2 Video Bioinformatics Background
3 Stem Cells Background
4 Instrumentation used to Collect Live Cell Video Data
5 Software used for Video Bioinformatics Analysis of Stem Cells in Toxciological Applications
6 Applications to Pluripotent Stem Cells
7 Application to Differentiating Stem Cells
8 Analysis, Computation, and Future Directions
9 Conclusions
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