In Vitro Toxicology Systems 1st Edition by Anna Bal Price, Paul Jennings ISBN 1493905201 9781493905201

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ISBN 10: 1493905201 
ISBN 13: 9781493905201
Author: Anna Bal Price, Paul Jennings

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches.

Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.

In Vitro Toxicology Systems 1st Table of contents:

1. Introduction to In Vitro Toxicology

• Overview of Toxicology

• Advantages of In Vitro Systems

• Regulatory Perspectives

2. Cell Culture Models

• Types of Cells Used in Toxicology

• Primary Cells vs. Cell Lines

• Three-Dimensional Cultures

3. Assays for Cytotoxicity

• Viability and Proliferation Assays

• Membrane Integrity Tests

• Metabolic Activity Assays

4. Mechanistic Toxicology

• Genotoxicity Testing

• Oxidative Stress Assays

• Apoptosis and Necrosis

5. High-Throughput Screening Methods

• Automation in Toxicology

• Data Analysis and Interpretation

• Screening Libraries and Compound Selection

6. Organotypic and Microphysiological Systems

• Liver and Kidney Models

• Lung and Skin Models

• Multi-Organ Systems

7. Application of In Vitro Systems in Drug Development

• Early Toxicity Screening

• Predictive Models for Human Toxicity

• Case Studies

8. Challenges and Limitations

• Reproducibility and Standardization

• Scaling from In Vitro to In Vivo

• Ethical Considerations

9. Future Directions in In Vitro Toxicology

• Advances in Stem Cell Technologies

• Integration with Computational Models

• Personalized Toxicology

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Tags: Anna Bal Price, Paul Jennings, Toxicology Systems