Statins in general practice 2nd Edition by Allan Gaw – Ebook PDF Instant Download/Delivery: 1841843504, 9781841843506
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Product details:
ISBN 10: 1841843504
ISBN 13: 9781841843506
Author: Allan Gaw
Statins in general practice 2nd Table of contents:
1 Why do we use statins?
Risk factors for CHD
Dyslipidaemia
Cholesterol and low-density lipoproteins (LDL)
High-density lipoprotein (HDL) cholesterol
Atherosclerosis
Plaque rupture and thrombosis
Regression of the atherosclerotic plaque
Clinical manifestations of atherosclerosis
Clinical picture of CHD
Diagnosis of CHD
2 How do we assess dyslipidaemia?
Lipid profiles
Timing of samples: when to measure
Interpretation of results
Clinical Disorders of lipid metabolism
Classification of dyslipidaemia
3 What are the statins and how do they work?
Discovery
Mechanism of action
Comparative pharmacokinetics
Mechanisms beyond cholesterol lowering
Statins and plaque stabilization
Statins and endothelial function
Statins and cellular immunity
Statins and inflammation
Statins and lipoprotein oxidation
Statins, rheology and blood coagulation
Statins and diabetes
Clinical use
Drug-drug interactions
4 What evidence do we have that statins work?
Scandinavian Simvastatin Survival Study: 4S
Results
West of Scotland Coronary Prevention Study: WOSCOPS
Cholesterol and Recurrent Events: CARE
Air Force/Texas Coronary Atherosclerosis Prevention Study: AF/TexCAPS
Long-term Intervention with Pravastatin in Ischaemic Disease: LIPID
Atorvastatin Versus Revascularization Treatment: AVERT
Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering: MIRACL
Pravastatin Pooling Project: PPP
Heart Protection Study: HPS
5 Who should receive statin therapy?
Evidence base
Risk assessment
6 What about statin use in the elderly?
Prospective Study of Pravastatin in the Elderly at Risk: PROSPER
7 What does the future hold?
Unanswered questions
Should statins be used in diabetes?
Should statins be used to prevent stroke?
Which statin is best?
Which dose is best?
What about alternatives to statins?
How can patient compliance be improved?
What are the barriers to prescribing statins?
Statin prescribing tomorrow
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