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Matrix Metalloproteinase Inhibitors in Cancer Therapy 1st Edition by Mark D Sternlicht, Lisa M Coussens, Neil J Clendeninn, Krzysztof Appelt ISBN 1617371238 9781617371233

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Matrix Metalloproteinase Inhibitors in Cancer Therapy 1st Edition Mark D. Sternlicht Phd Digital Instant Download

Author(s): Mark D. Sternlicht PhD, Lisa M. Coussens PhD (auth.), Neil J. Clendeninn MD, PhD, Krzysztof Appelt PhD (eds.)
ISBN(s): 9781617371233, 1617371238
Edition: 1
File Details: PDF, 6.97 MB
Year: 2001
Language: english
SKU: EB-11851138 Category: Tags: , , , ,

Matrix Metalloproteinase Inhibitors in Cancer Therapy 1st Edition by Mark D Sternlicht, Lisa M Coussens, Neil J Clendeninn, Krzysztof Appelt – Ebook PDF Instant Download/Delivery: 1617371238, 9781617371233
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Product details:

ISBN 10: 1617371238 
ISBN 13: 9781617371233
Author: Mark D Sternlicht, Lisa M Coussens, Neil J Clendeninn, Krzysztof Appelt

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.

Matrix Metalloproteinase Inhibitors in Cancer Therapy 1st Table of contents:

Chapter 1 Biology and Regulation of the Matrix Metalloproteinases
1. INTRODUCTION
2. COLLAGENASES
3. GELATINASES
4. STROMELYSINS 1 AND 2
5. MATRILYSIN
6. MEMBRANE-TYPE MMPS
7. STROMELYSIN-3
8. METALLOELASTASE
9. ENAMELYSIN
10. MMP-19
11. OTHER MMPS
12. TISSUE INHIBITORS OF METALLOPROTEINASES
13. CONCLUDING REMARKS
ACKNOWLEDGMENTS
REFERENCES
Chapter 2 Substrate Specificity of MMPs
1. INTRODUCTION
2. ACTIONS ON PROTEIN SUBSTRATES
3. PEPTIDE SUBSTRATE SPECIFICITY
4. CONCLUSIONS
ACKNOWLEDGMENTS
REFERENCES
Chapter 3 The Tissue Inhibitors of Metalloproteinases (TIMPs)
1. INTRODUCTION
2. TIMPs AND ADAMs
3. TIMP STRUCTURE
4. TIMPs AND CELL GROWTH
5. TIMPs AND APOPTOSIS
6. TIMP-3 AND SORSBY’S FUNDUS DYSTROPHY
7. TUMOR GROWTH, METASTASIS, AND ANGIOGENESIS
8. TIMP GENE EXPRESSION
9. FUTURE DIRECTIONS
ACKNOWLEDGMENTS
REFERENCES
Chapter 4 Matrix Metalloproteinases in Cancer
1. INTRODUCTION
2. MMP EXPRESSION IN HUMAN TUMORS
3. MMPS IN TUMOR INVASION AND METASTASIS
4. EXTENDED ROLES FOR MMPS IN TUMOR DEVELOPMENT AND PROGRESSION
5. SUMMARY AND CONCLUSION
REFERENCES
Chapter 5 Hydroxamic Acid Matrix Metalloproteinase Inhibitors
1. INTRODUCTION
2. MEDICINAL CHEMISTRY
3. PHARMACOLOGICAL EFFECTS IN DISEASE MODELS
4. CLINICAL DEVELOPMENT
5. CONCLUSION
ACKNOWLEDGMENTS
REFERENCES
Chapter 6 Prinomastat
1. INTRODUCTION
2. PRECLINICAL PHARMACOLOGY
3. PRINOMASTAT CLINICAL DEVELOPMENT
ACKNOWLEDGMENTS
REFERENCES
Chapter 7 A Potent Nonpeptidic Matrix Metalloproteinase Inhibitor
1. INTRODUCTION
2. RANDOM SCREENING AT BAYER
3. OPTIMIZATION OF THE SCREENING HIT
4. PRECLINICAL ACTIVITY
5. PRECLINICAL DRUG SAFETY ASSESSMENT
6. PHASE I CLINICAL RESULTS
REFERENCES
Chapter 8 D1927 and D2163
1. INTRODUCTION AND OBJECTIVES
2. INHIBITOR DESIGN
3. LEAD OPTIMIZATION OF PROTOTYPE MMP INHIBITORS
4. PROCESS OPTIMIZATION
5. PRECLINICAL EVALUATION OF D1927 AND D2163
ACKNOWLEDGMENTS
REFERENCES
Chapter 9 Research on MMP Inhibitors with Unusual Scaffolds
1. INTRODUCTION
2. INHIBITOR DESIGN STRATEGIES
3. SUMMARY AND OUTLOOK
ACKNOWLEDGMENT
REFERENCES
Chapter 10 Matrix Metalloproteinase Inhibitors
1. INTRODUCTION
2. ARTHRITIS
3. PERIODONTAL DISEASE
4. OPHTHALMOLOGY
5. NEUROLOGICAL DISEASES
6. CARDIOVASCULAR DISEASE

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Mark D Sternlicht,Lisa M Coussens,Neil J Clendeninn,Krzysztof Appelt,Matrix Metalloproteinase,Cancer