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RGS protein physiology and pathophysiology 1st Edition by Rory A Fisher ISBN 0128029382 9780128029381

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RGS protein physiology and pathophysiology 1st Edition Fisher Digital Instant Download

Author(s): Fisher, Rory A
ISBN(s): 9780128029381, 0128029382
Edition: 1
File Details: PDF, 6.19 MB
Year: 2015
Language: english
SKU: EB-5431800 Category: Tags: ,

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ISBN 10: 0128029382
ISBN 13: 9780128029381
Author: Rory A Fisher

RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo.

Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery.

The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics.

  • Brings together information on the current state of the RGS protein field
  • Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking
  • Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery

RGS protein physiology and pathophysiology 1st Table of contents:

Chapter One: Introduction: G Protein-coupled Receptors and RGS Proteins

  • Abstract

  • 1 GPCR Physiology, Pathophysiology, and Pharmacology

  • 2 GPCR Signal Transduction: Heterotrimeric G Proteins

  • 3 G Protein Regulation

  • 4 RGS Proteins

Chapter Two: RGS-Insensitive G Proteins as In Vivo Probes of RGS Function

  • Abstract

  • 1 Introduction

  • 2 Genetic Models of the Role of RGS in Physiology and Pathophysiology

  • 3 RGS Knockouts Versus RGS-Insensitive Gα Knock-In Models

  • 4 Phenotypes of Gαi2 G184S Mutant Knock-In Mice

  • 5 Observed Phenotypes with Gαo+/G184S Knock-In Mice

  • 6 Summary and Conclusions

Chapter Three: RGS Protein Regulation of Phototransduction

  • Abstract

  • 1 Introduction

  • 2 From Photon to a Neural Signal: The Wonder of Phototransduction

  • 3 The Need for Speed: Discrepancy on G-Protein Shutoff During Phototransduction Recovery

  • 4 Cannot Do It Alone: The Transducin GAP Is a Protein Complex

  • 5 Translocation and Regulation of RGS9-1

  • 6 Conclusions: Emerging Functions of RGS Proteins in the Visual System

Chapter Four: Role of Regulators of G Protein Signaling Proteins in Bone Physiology and Pathophysiology

  • Abstract

  • 1 Introduction to Bone

  • 2 The GPCR–G Protein–RGS Signaling Pathway

  • 3 RGS Proteins in Osteoblasts

  • 4 RGS Proteins in Osteoclasts

  • 5 GPCR–RGS Proteins Signaling in Skeletal Physiology

  • 6 GPCR/RGS Signaling in Skeletal Disorders

  • 7 Conclusion and Perspectives

  • Acknowledgments

Chapter Five: Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function

  • Abstract

  • 1 Introduction

  • 2 Structure and Biochemical Functions of RGS2

  • 3 Regulation of RGS2 Expression

  • 4 Expression of RGS2 in the Cardiovascular System

  • 5 RGS2 Function in the Vasculature

  • 6 RGS2 and Human Hypertension

  • 7 RGS2 in Preeclampsia

  • 8 RGS2 in Other Disorders Affecting Smooth Muscle

  • 9 Conclusions and Future Perspectives

  • Acknowledgments

Chapter Six: Keeping the Balance Right: Regulator of G Protein Signaling 5 in Vascular Physiology and Pathology

  • Abstract

  • 1 Regulator of G Protein Signaling Molecules in the Cardiovascular System

  • 2 RGS5: An Emerging Player in the Cardiovascular System

  • 3 RGS5 and Cardiovascular Pathologies

  • 4 Dynamic Regulation of RGS5 Levels

  • 5 RGS5 and vSMC Phenotypic Plasticity: Jack of All Trades, Master of None?

  • 6 The Cardiovascular RGS Family: It’s a Fine Balance

  • 7 Challenges in the Field

  • Acknowledgments

Chapter Seven: Two for the Price of One: G Protein-Dependent and -Independent Functions of RGS6 In Vivo

  • Abstract

  • 1 Introduction

  • 2 Regulation of G Protein Signaling by RGS6 In Vivo

  • 3 G Protein-Independent RGS6 Signaling Actions

  • 4 Conclusions and Future Directions

  • Acknowledgments

Chapter Eight: Physiology of RGS10 in Neurons and Immune Cells

  • Abstract

  • 1 Introduction: The Basic Structure and Isoforms of RGS10

  • 2 Regulation of G Protein Signaling and Its Interacting Partners

  • 3 Role of RGS10 as a Negative Regulator of Neuroinflammation

  • 4 RGS10 in Peripheral Immune Cells

  • 5 RGS10 in Pathophysiological States

Chapter Nine: Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory

  • Abstract

  • 1 Introduction

  • 2 Molecular Characterization and the Cellular Functions, Localization, and Regulation of RGS14

  • 3 RGS14 Naturally Limits Learning and Synaptic Plasticity in Hippocampal CA2

  • 4 Potential Roles for RGS14 and CA2 in Human Behavior and Disease

  • 5 Summary and Perspectives

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Tags: Rory A Fisher, protein physiology, pathophysiology