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Intramembrane Cleaving Proteases I CLiPs 1st Edition by Nigel M Hooper, Uwe Lendeckel ISBN 1402063113 9781402063114

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Intramembrane Cleaving Proteases I CLiPs Proteases in Biology and Disease 1st Edition Nigel M. Hooper (Editor) Digital Instant Download

Author(s): Nigel M. Hooper (Editor), Uwe Lendeckel (Editor)
ISBN(s): 9781402063114, 1402063113
Edition: 1
File Details: PDF, 2.41 MB
Year: 2007
Language: english
SKU: EB-1679024 Category: Tags: ,

Intramembrane Cleaving Proteases I CLiPs 1st Edition by Nigel M Hooper, Uwe Lendeckel – Ebook PDF Instant Download/Delivery: 1402063113, 9781402063114
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ISBN 10: 1402063113 
ISBN 13: 9781402063114
Author: Nigel M Hooper, Uwe Lendeckel

In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.

Intramembrane Cleaving Proteases I CLiPs 1st Table of contents:

The Site-2 Protease at Ten
Robert B. Rawson, Wei-ping Li
Pages 1-15
Signal Peptide Peptidases
Todd E. Golde, Criag Zwizinski, Andrew Nyborg
Pages 17-30
GXGD-Type Intramembrane Proteases
Harald Steiner, Christian Haass
Pages 31-49
Rhomboid Intramembrane Serine Proteases
Sinisa Urban
Pages 51-77
Proteases of the Rhomboid Family in the Yeast Saccharomyces Cerevisiae
Elke Pratje
Pages 79-88
γ-Secretase And Alzheimer’S Disease
Michael S. Wolfe
Pages 89-109
γ-Secretase Mediated Proteolysis: At the Cutting Edge of Notch Signaling
Ma. Xenia G. Ilagan, Dilip Chandu, Raphael Kopan
Pages 111-140

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Nigel M Hooper,Uwe Lendeckel,Intramembrane,Proteases I CLiPs