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Molecular Biology of B Cells 2nd Edition by Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt ISBN 0123984904 9780123984906

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Molecular Biology of B Cells 2nd Edition Tasuku Honjo Digital Instant Download

Author(s): Tasuku Honjo; Michael Reth; Andreas Radbruch; Frederick Alt
ISBN(s): 9780123984906, 0123984904
Edition: 2
File Details: PDF, 41.56 MB
Year: 2015
Language: english
SKU: EB-4926242 Category: Tags: , , ,

Molecular Biology of B Cells 2nd Edition by Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt – Ebook PDF Instant Download/Delivery: 0123984904, 9780123984906
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ISBN 10: 0123984904 
ISBN 13: 9780123984906
Author: Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.

Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality.  The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application.  With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.

Molecular Biology of B Cells 2nd Table of contents:

Chapter 1. The Structure and Regulation of the Immunoglobulin Loci

  1. Introduction

  2. Genomic Organization of the Mouse Immunoglobulin Heavy Chain Locus

  3. Genomic Organization of the Mouse Immunoglobulin Kappa Light Chain Locus

  4. Genomic Organization of the Mouse Immunoglobulin Lambda Light Chain Locus

  5. B Cell Development and Regulation of V(D)J Recombination

  6. Junctional Diversity

  7. Combinatorial Diversity

  8. Noncoding Transcription and Immunoglobulin Locus Rearrangement

  9. The Process of Dh–Jh Recombination

  10. Epigenetics and Immunoglobulin Locus Rearrangement

  11. Insulators and Immunoglobulin Locus Rearrangement

  12. 3D Structure and Compaction of the Immunoglobulin Heavy Chain Locus

  13. Conclusion

Chapter 2. The Mechanism of V(D)J Recombination

  1. Overview

  2. Antigen Receptor Gene Assembly

  3. Recombination Signal Sequences

  4. Biochemistry of V(D)J Cleavage

  5. RAG1 and RAG2

  6. A Role for HMGB1 in V(D)J Recombination

  7. Recombination Complexes: Analysis of Stoichiometry and Organization

  8. V(D)J Recombination Is Tightly Regulated during Lymphocyte Development

  9. Accessibility Model of Regulation

  10. Overview of Chromatin Structure

  11. Regulation by Nucleosome Structure and Histone Acetylation

  12. Regulation by Histone Methylation

  13. How Is the Chromatin Structure of Antigen Receptor Loci Developmentally Regulated?

  14. Additional Layers of Regulation

  15. Regulation of V(D)J Recombination: Summary

  16. Oncogenic Lesions in Lymphoid Neoplasms: The Price of a Diverse Antigen Receptor Repertoire

  17. Proposed Mechanisms Underlying RAG-Mediated Genomic Lesions

  18. Regulatory Controls Proposed to Suppress RAG-Mediated Genomic Instability

  19. V(D)J Recombination Errors as Pathogenic Lesions in Lymphoid Neoplasms: Summary

Chapter 3. Transcriptional Regulation of Early B Cell Development

  1. PU.1 Sets the Stage for Lymphoid and Myeloid Development

  2. Lineage Priming in Lymphoid Progenitors by Ikaros

  3. E2A Regulates the Chromatin Landscape to Promote Gene Expression in B Cell Development

  4. E2A Is Inhibited by Id Proteins

  5. Interleukin-7/Stat5 Signaling Provides an Early Signal for B Cell Lineage Specification

  6. Early B Cell Factor: Central Coordinator of B Cell Development

  7. Collaboration between EBF1 and Foxo1

  8. Regulation of the B Cell–Specific Program by Pax5

  9. Regulation of B Lineage Commitment

  10. Conclusion

Chapter 4. Relationships among B Cell Populations Revealed by Global Gene Analysis

  1. Introduction

  2. Gene Profile Changes with B Cell Maturation Suggest an Ordering of Transitional Stages

  3. Distinctions in Gene Networks Activated in Mature B Cell Populations

  4. Fo/B2 B Cells in Different Tissues are Similar, but Specialization with Location Emerges

  5. Conclusions

Chapter 5. Roles of MicroRNAs in B Lymphocyte Physiology and Oncogenesis

  1. Introduction

  2. Control of Cell Survival and Proliferation by Mir-17∼92 in B Cell Development and Lymphomagenesis

  3. The Problem of MiRNA Target Identification and Validation

  4. Mir-155 in Germinal Center B Cells and Lymphomagenesis

  5. Discovery of an Elusive Tumor Suppressor: Mir-15a∼16-1 Cluster

  6. Lin28b Regulates the Fetal–Adult B Cell Development Switch

  7. To Be Further Determined

  8. Concluding Remarks

Chapter 6. Proliferation and Differentiation Programs of Developing B Cells

  1. Proliferation and Differentiation Programs at the Pro-B Cell Stage

  2. Proliferation and Differentiation Programs at the Pre-B Cell Stage

  3. Selection Mechanisms at the Immature B Cell Stage

Chapter 7. Development and Function of B Cell Subsets

  1. Introduction

  2. B-1, Marginal Zone and Follicular B Cells

  3. Mechanisms for the Compartmentalization of B-Cell Subsets

  4. Selection and Differential Survival Mechanisms: BCR Signaling, Composition, and Specificity

  5. Other Factors Involved in the Formation of B-Cell Subsets

  6. Homeostasis of B-Cell Subsets and Repertoires

  7. Conclusion

Chapter 8. B Cells and Antibodies in Jawless Vertebrates

  1. Introduction

  2. Lampreys and Hagfish Have Three Types of VLR Genes

  3. VLR Gene Assembly Mechanism and Sequence Diversity

  4. Lamprey CDA1 and CDA2

  5. VLRA, VLRB, and VLRC Are Expressed by Different Lymphocyte Populations

  6. Characterization of B-Like and Two T-Like Lymphocyte Populations in Cyclostomes

  7. VLRA+, VLRB+, and VLRC+ Cells Have Distinct Gene Expression Profiles

  8. Generation of the T-Like and B-Like Cells in Lampreys

  9. The Unique Structure of VLRB Antibodies

  10. VLRB Monoclonal Antibodies

  11. Structure of VLR Antigen-Binding Domains

  12. Structures of VLRB Antibody–Antigen Complexes

  13. Conclusion

Chapter 9. The Origin of V(D)J Diversification

  1. The Alien Seed

  2. The Evolution of BCR and TCR Loci

  3. Considerations on the ur-V Gene

  4. Concluding Remarks

Chapter 10. Structure and Signaling Function of the B-Cell Antigen Receptor and Its Coreceptors

  1. Introduction

  2. Basic Structure of the BCR Complex

  3. BCR Activation Models

  4. The Resting State of the BCR

  5. Interaction of the BCR with Signal-Transducing Kinases and Adaptors

  6. BCR Coreceptors CD19 and CD22

  7. CD19 Functions in a Complex with CD21 and CD81

  8. Signaling by the CD19 Tail

  9. Human Mutations in the CD19/Cd21/Cd81 Complex

  10. CD22: An Inhibitory Receptor

  11. Regulation of CD22 Signaling by Ligand Interactions

  12. The Role of CD22 in Preventing Autoimmunity

  13. BCR-Controlled Signaling Processes

  14. BCR-Mediated Adaptor and PLCγ2 Activation

  15. IP3 Promotes Calcium Release and Activation of Nuclear Factor of Activated T Cells

  16. DAG and Nuclear Factor-κB Activation

  17. Activation of the PI3K Pathway

  18. Akt and Foxo Regulation

Chapter 11. Fc and Complement Receptors

  1. Consequences of FCγRIIB Deficiency

  2. Consequences of Complement and Complement Receptor Deficiencies

  3. FC Receptors

  4. Complement Receptors

  5. Coreceptor Signaling versus Antigen Localization to FDCs

  6. Frontiers: Complement versus FC Receptors

Chapter 12. B Cell Localization and Migration in Health and Disease

  1. Introduction

  2. Migration of B Cells in the Bone Marrow

  3. Migration of B Cells into and within SLOs

  4. Location and Migration of Antibody-Secreting Cells

  5. Body Cavity B-1 B Cell Trafficking

  6. Mucosal B Cell Migration

  7. Homing of B Cells during Chronic Inflammation and Tertiary Lymphoid Organ Formation

  8. Migration of Neoplastic B Cells

  9. Conclusion

Chapter 13. B Cells as Regulators

  1. Introduction

  2. Regulatory Role of B Cells in UC

  3. Protective Function of B Cells in EAE

  4. Regulatory Roles of B Cells in Systemic Lupus Erythematosus

  5. Regulatory Role of B Cells in Bacterial Infections

  6. Characterization and Function of IL-10-Producing B Cells in Humans

  7. Concluding Remarks
    Conflict of Interest

Chapter 14. B Cell Memory and Plasma Cell Development
Chapter 14a. Generation of Memory B Cells
Chapter 14b. Plasma Cell Biology
Chapter 14c. Memory Plasma Cells

Chapter 15. The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology

  1. BAFF/APRIL: Important Regulators of B Cell Survival, Homeostasis, and Function

  2. The Lymphotoxin Pathway: Shaping B Cell Environments

  3. Conclusions and Perspectives

Chapter 16. The Mucosal Immune System: Host–Bacteria Interaction and Regulation of Immunoglobulin A Synthesis

  1. Introduction

  2. Geography, Regulation, and Properties of Gut Immunoglobulin A

  3. Synthesis of Gut Immunoglobulin A

  4. T Cell-Dependent Immunoglobulin A Induction

  5. T Cell-Independent Immunoglobulin A Induction

  6. Function of Immunoglobulin A

  7. Clinical Relevance

  8. Conclusions

Chapter 17. Gut Microbiota and Their Regulation

  1. Microbiota

  2. Microbes, Primary Ig Diversification, and Early Life B Cell Selection

  3. Microbial Influence on IgA Production

  4. Microbial Influence on IgE Production

  5. B-Lineage Cell Influence on Commensal Microbes

  6. Concluding Remarks

Chapter 18. Molecular Mechanisms of AID Function

  1. Introduction

  2. AID Structure and Function

  3. AID’s Molecular Mechanism of DNA Cleavage and Recombination

  4. The Mechanism of AID’s Specificity Determination for DNA Cleavage

  5. Regulation of AID Expression

  6. Concluding Remarks

Chapter 19. The Mechanism of IgH Class Switch Recombination

  1. Antibody Class

  2. Organization of Mouse IgH Locus

  3. A Two-Step Model of CSR

  4. Mechanisms by Which AID Initiates CSR and SHM

  5. Germline S Region Transcription Targets AID Activity during CSR

  6. Role of Transcription Stalling in AID Targeting

  7. AID Cofactors Facilitate AID Access to Its ssDNA Substrates

  8. Differential AID Targeting and Outcomes during CSR and SHM

  9. Long-Range Joining of S Region Breaks

  10. Classical Nonhomologous End Joining

  11. Alternative End Joining

  12. Chromosomal Translocation in Lymphomas Caused by Aberrant CSR

  13. Evolution of the IgH CSR Mechanism

Chapter 20. Somatic Hypermutation: The Molecular Mechanisms Underlying the Production of Effective High-Affinity Antibodies

  1. Introduction

  2. Activation-Induced Cytidine Deaminase in Somatic Hypermutation

  3. Targeting of the SHM

  4. Activation-Induced Cytidine Deaminase and Downstream Repair Pathways

  5. Mismatch Repair in Somatic Hypermutation

  6. Base Excision Repair in Somatic Hypermutation

  7. Conclusion

Chapter 21. Aberrant AID Expression by Pathogen Infection

  1. Introduction

  2. Physiologic Role of Activation-Induced Cytidine Deaminase

  3. AID Induction in B Cells

  4. Regulation of AID Expression in B Cells

  5. Aberrant AID Expression by Pathogen Infection and Tumorigenesis

  6. Conclusion

Chapter 22. Molecular Pathogenesis of B Cell Lymphomas

  1. Introduction

  2. The Cell of Origin of Lymphomas

  3. Mechanisms of Genetic Lesion in Lymphoma

  4. Molecular Pathogenesis of Most Common Lymphoma Types

Chapter 23. B Cells Producing Pathogenic Autoantibodies

  1. Origin of Autoantibodies

  2. Immunodeficiency, B Cell Malignancy, and Autoreactivity

  3. Features of Pathogenic Autoantibodies

  4. Effector Mechanisms of Pathogenic Autoantibodies

  5. B Cells as the Therapeutic Target in Autoimmune Disease

  6. Conclusion

Chapter 24. The Cellular and Molecular Biology of HIV-1 Broadly Neutralizing Antibodies

  1. Introduction

  2. Highly Conserved Structures on HIV-1 Env

  3. Mechanisms of HIV-1 Neutralization by Antibodies

  4. Role of Neutralizing Antibodies in Protection from HIV-1 Transmission

  5. Biology of Broad Neutralizing Antibody Development

  6. Characteristics of HIV-1 Env Neutralizing Antibodies

  7. HIV-1 Env Antibodies Induced by Current HIV Vaccine Candidates

  8. New Strategies for Induction of HIV-1 bnAbs

  9. Summary

Chapter 25. Immune Deficiencies Caused by B Cell Defects

  1. Defects in B Cell Development

  2. Defects in B Cell Migration

  3. Defects in B Cell Survival

  4. Defects in B Cell Activation

  5. PADs with Unknown Etiology

  6. Therapeutic Approaches

  7. Conclusion

Chapter 26. IMGT® Immunoglobulin Repertoire Analysis and Antibody Humanization

  1. IMGT® and the Birth of Immunoinformatics

  2. Fundamental Information from IMGT-ONTOLOGY Concepts

  3. IMGT® Immunoglobulin Repertoire Analysis

  4. IMGT® Antibody Engineering and Humanization

  5. Conclusion

  6. Availability and Citation

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Tags: Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt, Molecular Biology