Environmental Impacts on Reproductive Health and Fertility 1st Edition by Woodruff Tracey J – Ebook PDF Instant Download/Delivery: 0521519527, 9780521519526
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Product details:
ISBN 10: 0521519527
ISBN 13: 9780521519526
Author: Woodruff Tracey J
Environmental Impacts on Reproductive Health and Fertility 1st Table of contents:
Chapter 1: Introduction
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Background
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Scope of this Book
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Defining the Field
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Environmental Contaminants
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Critical and Sensitive Periods of Development and Susceptibility
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Sources of Scientific Information
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Layout of this Book
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References
Chapter 2: Environmental Contaminants and Exposure
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Introduction
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Understanding Exposure and Dose
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Basic Definitions
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Sources of Contaminants
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Timing and Populations of Concern
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From Exposure to Dose: Absorption, Distribution, Metabolism, Excretion
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Quantifying Dose
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Case Examples: Mercury, Organophosphate Pesticides, Phthalates
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Science and Policy Issues
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Summary
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References
Chapter 3: Development and Maturation of the Normal Female Reproductive System
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Ovary: Embryonic Development, Folliculogenesis, Reproductive Modulators
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Oviduct and Uterus: Development, Müllerian Ducts, Abnormalities
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Breast: Development, Hormone Receptors, Environmental Impacts, Endocrine Disruptors
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Summary
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References
Chapter 4: Development and Maturation of the Normal Male Reproductive System
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Key Periods in Development
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Fetal Period (Sexual Differentiation, Testicular Development)
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Neonatal, Pubertal, and Adult Development
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Summary
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References
Chapter 5: Modern Genetics of Reproductive Biology
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Epigenetics and Disease
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HOX Genes, Estrogen Receptors, and Female Reproductive Diseases
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Transgenerational Effects (e.g., DES)
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DNA Methylation and Environmental Factors
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Conclusions
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References
Chapter 6: Mechanisms of Endocrine Disruption
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Endocrine System Targets
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Genomic and Non-Genomic Modulation by EDCs
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Epigenetic Modulation
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DNA Methylation
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Histone Modification
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Transgenerational Effects
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Conclusions and Future Directions
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References
Chapter 7: Developmental Exposures and Implications for Early and Latent Disease
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Developmental Origins of Disease
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Prenatal and Neonatal Exposure to Endocrine Disruptors (e.g., DES)
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Reproductive Malformations, Puberty, and Adult Diseases
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Endometriosis, Fibroids, Cancer
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Mechanisms of Adverse Effects
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Summary
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References
Chapter 8: Wildlife as Sentinels of Environmental Impacts on Reproductive Health and Fertility
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Lessons from Wildlife
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Great Lakes, Lake Apopka, Alligators, Marine Mollusks
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Wildlife Biomarkers of Contaminant Exposure
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Summary
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References
Chapter 9: Environmental Contaminants and Effects on Pubertal Development
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Normal Puberty and Environmental Aspects
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Precocious Puberty and Endocrine Disruptors
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Possible Mechanisms of Action
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References
Chapter 10: Environmental Contaminants and Healthy Pregnancies
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Challenges in Studying Pregnancy and Environmental Effects
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Examples: Smoking, Air Pollutants, Metals, Pesticides
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Effects on Fetal Growth, Congenital Malformations, Pregnancy Complications
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Sex Ratio and Environmental Factors
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Conclusion
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References
Chapter 11: Environmental Contaminants and Male Reproductive Health
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Fetal Exposure
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Effects on Semen Quality, Trends in Male Reproductive Health
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Chemical Exposures (e.g., Phthalates, Pesticides)
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Adult Exposure
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Fertility Impacts (e.g., Organophosphates, Polychlorinated Biphenyls)
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Conclusions and Future Research
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References
Chapter 12: Environmental Contaminants and Female Reproductive Health
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In Utero Exposures
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Ovarian Dysgenesis Syndrome, Puberty, Polycystic Ovary Syndrome, Endometriosis
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Adult Exposures and Reproductive Health
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Menstrual Function, Fertility, Endometriosis, Menopause
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Clinical and Public Health Implications
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Future Research Directions
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References
Chapter 13: Environmental Contaminants and Related Systems Affecting Reproduction
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Neuroendocrine System: Impact of EDCs on Reproductive Hormone Regulation
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Thyroid System: Environmental Impacts on Thyroid Function
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Immune System: Hormonal Disruption and Reproductive Outcomes
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References
Chapter 14: Environmental Contaminants and Cancers of the Reproductive Tract
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Testicular Cancer, Prostate Cancer, Breast Cancer, Ovarian Cancer, Endometrial Cancer
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Role of Estrogens, Persistent Organic Pollutants, Pesticides, Heavy Metals
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Summary
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References
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