Ocular transporters and receptors Their role in drug delivery 1st Edition by Ashim Mitra 9781907568862 1907568867

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ISBN 10: 1907568867
ISBN 13: 9781907568862 
Author: Ashim K. Mitra

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.

Ocular transporters and receptors Their role in drug delivery 1st Table of contents:

• 1. Eye: Anatomy, Physiology and Barriers to Drug Delivery
  • 1.1 Introduction
  • 1.2 Anatomy and Physiology of the Eye
  • 1.3 Barriers to Ocular Drug Delivery
  • 1.4 Conclusions
  • 1.5 Acknowledgements
  • 1.6 References
• 2. Biology of Ocular Transporters: Efflux and Influx Transporters in the Eye
  • 2.1 Introduction
  • 2.2 SLC Transporters
  • 2.3 ABC Transporters
  • 2.4 Conclusions
  • 2.5 References
• 3. Characterization of Ocular Transporters
  • 3.1 Introduction
  • 3.2 Molecular and Cellular Characterization
  • 3.3 Functional Characterization of Transporters
  • 3.4 References
• 4. Transporters and Receptors in the Anterior Segment of the Eye
  • 4.1 Introduction
  • 4.2 Transporters and Receptors
  • 4.3 Anterior Chamber Influx Transporters
  • 4.4 Anterior Chamber Efflux Transporters
  • 4.5 Anterior Chamber Receptors
  • 4.6 Other Miscellaneous Anterior Chamber Receptors
  • 4.7 Conclusions
  • 4.8 References
• 5. Transporters and Receptors in the Posterior Segment of the Eye
  • 5.1 Introduction
  • 5.2 Influx Transporters in Posterior Segment of the Eye
  • 5.3 Receptors in Posterior Segment of the Eye
  • 5.4 ABC Transporters
  • 5.5 Conclusion
  • 5.6 References
• 6. Transporters in Drug Discovery and Delivery: A New Paradigm in Ocular Drug Design
  • 6.1 Introduction
  • 6.2 Transporter-Targeted Drug Delivery to the Anterior Segment
  • 6.3 Transporter-Targeted Drug Delivery to the Posterior Segment
  • 6.4 Conclusion
  • 6.5 References
• 7. Transporter–Metabolism Interplay in the Eye
  • 7.1 Introduction
  • 7.2 Metabolizing Enzymes in Ocular Tissues
  • 7.3 Impact of Disease State on the Expression of Metabolizing Enzymes
  • 7.4 Efflux Transporters and Metabolism Interplay
  • 7.5 Potential Impact of the Efflux–Metabolism Interplay in Ocular Bioavailability
  • 7.6 Drug Design and Formulation Strategies to Overcome the Efflux and Metabolism Interplay
  • 7.7 Conclusion
  • 7.8 References
• Index

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Tags: Ashim Mitra, Ocular, transporters